6-tert-butyl-1-(toluene-4-sulfonyl)-1-aza-spiro[2.5]octane

Base Information

• Chemical Name: 6-tert-butyl-1-(toluene-4-sulfonyl)-1-aza-spiro[2.5]octane
• CAS No.: 862115-10-4
• Molecular Formula: C₁₈H₂₇NO₂S
• Molecular Weight: 321.484
• Mol file: 862115-10-4.mol

Synonyms:6-tert-butyl-1-(toluene-4-sulfonyl)-1-aza-spiro[2.5]octane

Chemical Property of 6-tert-butyl-1-(toluene-4-sulfonyl)-1-aza-spiro[2.5]octane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-tert-butyl-1-(toluene-4-sulfonyl)-1-aza-spiro[2.5]octane

There total 1 articles about 6-tert-butyl-1-(toluene-4-sulfonyl)-1-aza-spiro[2.5]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

1-tert-butyl-4-methylenecyclohexane (13294-73-0) + chloroamine-T (127-65-1) → 6-tert-butyl-1-(toluene-4-sulfonyl)-1-aza-spiro[2.5]octane (862115-10-4)

Guidance literature:

With N-Bromosuccinimide; 7; at 20 ℃;

DOI:10.1021/ol050965t

Reference yield: 79.0%

6-tert-butyl-1-(toluene-4-sulfonyl)-1-aza-spiro[2.5]octane (862115-10-4) + 2-bromo-2-(2-ethyl)dioxolane (18742-02-4) → N-[4-tert-butyl-1-(3-[1,3]dioxolan-2-yl-propyl)-cyclohexyl]-4-methylbenzenesulfonamide

Guidance literature:

2-bromo-2-(2-ethyl)dioxolane; With magnesium; In tetrahydrofuran; at 25 ℃;

With copper(I) bromide dimethylsulfide complex; dimethylsulfide; In tetrahydrofuran; at -78 ℃; for 1h;

6-tert-butyl-1-(toluene-4-sulfonyl)-1-aza-spiro[2.5]octane; In tetrahydrofuran; at -78 - 25 ℃;

DOI:10.1021/ol0610789

Reference yield: 75.0%

6-tert-butyl-1-(toluene-4-sulfonyl)-1-aza-spiro[2.5]octane (862115-10-4) + 3-hydroxy-2-methyl-1-propene (513-42-8) → N-[4-tert-butyl-1-(3-hydroxymethyl-but-3-enyl)-cyclohexyl]-4-methyl-benzenesulfonamide (862115-11-5)

Guidance literature:

3-hydroxy-2-methyl-1-propene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; at 0 - 20 ℃; for 2h;

With magnesium bromide; In diethyl ether; at 0 - 20 ℃;

6-tert-butyl-1-(toluene-4-sulfonyl)-1-aza-spiro[2.5]octane; In diethyl ether; at 25 ℃; for 2h;

DOI:10.1021/ol050965t

upstream raw materials:

1-tert-butyl-4-methylenecyclohexane

chloroamine-T

Downstream raw materials:

N-[4-tert-butyl-1-(3-hydroxymethyl-but-3-enyl)-cyclohexyl]-4-methyl-benzenesulfonamide