2-(Benzyl-formyl-amino)-N-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-phenyl-acetamide

Base Information

Chemical Name:2-(Benzyl-formyl-amino)-N-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-phenyl-acetamide
CAS No.:219924-12-6
Molecular Formula:C₂₉H₃₆N₂O₃Si
Molecular Weight:488.702
Hs Code.:

Synonyms:2-(Benzyl-formyl-amino)-N-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-phenyl-acetamide

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Chemical Property of 2-(Benzyl-formyl-amino)-N-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-phenyl-acetamide

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Technology Process of 2-(Benzyl-formyl-amino)-N-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-phenyl-acetamide

There total 5 articles about 2-(Benzyl-formyl-amino)-N-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-phenyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-18-6
formic acid

: 100-52-7
benzaldehyde

: 100-46-9
benzylamine

: 219924-10-4
tert-butyl-[(2-isocyanophenyl)methoxy]dimethylsilane

: 219924-12-6
2-(Benzyl-formyl-amino)-N-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-phenyl-acetamide

Guidance literature:: With zinc(II) chloride; In tetrahydrofuran; at 0 ℃; for 72h;
DOI:10.1021/jo982186e

Reference yield:

: 5344-90-1
2-Aminobenzyl alcohol

: 219924-12-6
2-(Benzyl-formyl-amino)-N-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / sodium hydride / tetrahydrofuran / 0 - 20 °C

2: 95 percent / pyridine / tetrahydrofuran / Ambient temperature

3: 80 percent / DABCO, triphosgene / CH₂Cl₂ / 1 h / 0 °C

4: ZnCl₂ / tetrahydrofuran / 72 h / 0 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; bis(trichloromethyl) carbonate; sodium hydride; zinc(II) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo982186e

Reference yield:

: 68847-33-6
2-[(1,1,2,2-tetramethyl-1-silapropoxy)methyl]phenylamine

: 219924-12-6
2-(Benzyl-formyl-amino)-N-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / pyridine / tetrahydrofuran / Ambient temperature

2: 80 percent / DABCO, triphosgene / CH₂Cl₂ / 1 h / 0 °C

3: ZnCl₂ / tetrahydrofuran / 72 h / 0 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; bis(trichloromethyl) carbonate; zinc(II) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo982186e