(dl)-N_α-Benzoylhistidine methylamide

Base Information

• Chemical Name: (dl)-N_α-Benzoylhistidine methylamide
• CAS No.: 120546-75-0
• Molecular Formula: C₁₄H₁₆N₄O₂
• Molecular Weight: 272.307
• Mol file: 120546-75-0.mol

Synonyms:(dl)-N_α-Benzoylhistidine methylamide

Chemical Property of (dl)-N_α-Benzoylhistidine methylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (dl)-N_α-Benzoylhistidine methylamide

There total 1 articles about (dl)-N_α-Benzoylhistidine methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

N-α-Benzoylhistidine methyl ester (120546-89-6) + methylamine (74-89-5) → (dl)-Nα-Benzoylhistidine methylamide (120546-75-0)

Guidance literature:

In water; for 6h; Heating;

DOI:10.1021/ja00195a049

Reference yield: 54.0%

methyl vinyl ketone (78-94-4,25038-87-3) + (dl)-Nα-Benzoylhistidine methylamide (120546-75-0) → (dl)-Nα-Benzoyl-N-1-(3-oxobut-1-yl)histidine methylamide (120546-83-0)

Guidance literature:

In tetrahydrofuran; water; for 15h; Ambient temperature; pH = 10.00;

DOI:10.1021/ja00195a049

Reference yield: 29.0%

(dl)-Nα-Benzoylhistidine methylamide (120546-75-0) + bicyclomycin (38129-37-2) → 2-({3-[4-(2-Benzoylamino-2-methylcarbamoyl-ethyl)-imidazol-1-ylmethyl]-2-hydroxy-tetrahydro-furan-2-carbonyl}-amino)-3,4-dihydroxy-4-methyl-tetrahydro-furan-2-carboxylic acid amide (120546-81-8)

Guidance literature:

In tetrahydrofuran; water; for 20h; Ambient temperature; pH = 9.90;

DOI:10.1021/ja00195a049

upstream raw materials:

N-_α-Benzoylhistidine methyl ester

methylamine

Downstream raw materials:

(dl)-N_α-Benzoyl-N-1-(3-oxobut-1-yl)histidine methylamide

2-({3-[4-(2-Benzoylamino-2-methylcarbamoyl-ethyl)-imidazol-1-ylmethyl]-2-hydroxy-tetrahydro-furan-2-carbonyl}-amino)-3,4-dihydroxy-4-methyl-tetrahydro-furan-2-carboxylic acid amide