Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate

Base Information

Chemical Name:Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate
CAS No.:144060-69-5
Molecular Formula:C₁₃H₁₁ClN₂O₄S
Molecular Weight:326.76
Hs Code.:
DSSTox Substance ID:DTXSID701173708

Synonyms:Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate;SCHEMBL8867203;QLRKACSNVXVLNL-UHFFFAOYSA-N;DTXSID701173708;144060-69-5

Suppliers and Price of Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:326.0128057
Heavy Atom Count:21
Complexity:406

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C(S1)C2=CC(=C(C=C2)Cl)[N+](=O)[O-])C

Technology Process of Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate

There total 4 articles about Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 871933-36-7
4-chloro-3-nitrobenzenecarbothioamide

: 609-15-4
ethyl 2-chloro-3-oxo-butyrate

: 144060-69-5
ethyl 2-(4-chloro-3-nitrophenyl)-4-methylthiazole-5-carboxylate

Guidance literature:: In ethanol; at 110 ℃;
DOI:10.1021/jm201546m

Reference yield:

: 16588-06-0
4-chloro-3-nitrobenzamide

: 144060-69-5
ethyl 2-(4-chloro-3-nitrophenyl)-4-methylthiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Lawessons reagent / 1,4-dioxane / 2 h / 110 °C

2: ethanol / 110 °C

With Lawessons reagent; In 1,4-dioxane; ethanol;
DOI:10.1021/jm201546m

Reference yield:

: 939-80-0
4-chloro-3-nitrobenzonitrile

: 144060-69-5
ethyl 2-(4-chloro-3-nitrophenyl)-4-methylthiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 60 °C

2: Lawessons reagent / 1,4-dioxane / 2 h / 110 °C

3: ethanol / 110 °C

With Lawessons reagent; dihydrogen peroxide; potassium carbonate; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm201546m