(2R,3R)-N-methoxy-N-methyl-2-benzyl-3-(benzyloxycarbonylamino)-4-hydroxybutanamide

Base Information

Chemical Name:(2R,3R)-N-methoxy-N-methyl-2-benzyl-3-(benzyloxycarbonylamino)-4-hydroxybutanamide
CAS No.:349148-58-9
Molecular Formula:C₂₁H₂₆N₂O₅
Molecular Weight:386.448
Hs Code.:

Synonyms:(2R,3R)-N-methoxy-N-methyl-2-benzyl-3-(benzyloxycarbonylamino)-4-hydroxybutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-N-methoxy-N-methyl-2-benzyl-3-(benzyloxycarbonylamino)-4-hydroxybutanamide

Chemical Property:

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Technology Process of (2R,3R)-N-methoxy-N-methyl-2-benzyl-3-(benzyloxycarbonylamino)-4-hydroxybutanamide

There total 3 articles about (2R,3R)-N-methoxy-N-methyl-2-benzyl-3-(benzyloxycarbonylamino)-4-hydroxybutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 349148-56-7
(3R,4R)-3-benzyl-4-(N-benzyloxycarbonylamino)-butyrolactone

: 349148-58-9
(2R,3R)-N-methoxy-N-methyl-2-benzyl-3-(benzyloxycarbonylamino)-4-hydroxybutanamide

Guidance literature:: With trimethylaluminum; In hexane; dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jo0014055

Reference yield:

: 100-39-0
benzyl bromide

: 349148-58-9
(2R,3R)-N-methoxy-N-methyl-2-benzyl-3-(benzyloxycarbonylamino)-4-hydroxybutanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / hexamethylphosphoric acid triamide; tetrahydrofuran / 2 h / -78 °C

1.2: hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / -78 °C

2.1: AlMe₃ / CH₂Cl₂; hexane / 1 h / 20 °C

With trimethylaluminum; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;
DOI:10.1021/jo0014055

Reference yield:

: 118399-28-3
(R)-4-benzyloxycarbonylamino-4,5-dihydro-2(3H)-furanone

: 349148-58-9
(2R,3R)-N-methoxy-N-methyl-2-benzyl-3-(benzyloxycarbonylamino)-4-hydroxybutanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / hexamethylphosphoric acid triamide; tetrahydrofuran / 2 h / -78 °C

1.2: hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / -78 °C

2.1: AlMe₃ / CH₂Cl₂; hexane / 1 h / 20 °C

With trimethylaluminum; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;
DOI:10.1021/jo0014055