N^α-formyl-N^Ε-CBZ-L-lysine

Base Information

• Chemical Name: N^α-formyl-N^Ε-CBZ-L-lysine
• CAS No.: 53917-47-8
• Molecular Formula: C₁₅H₂₀N₂O₅
• Molecular Weight: 308.334
• Mol file: 53917-47-8.mol

Synonyms:N^α-formyl-N^Ε-CBZ-L-lysine

Chemical Property of N^α-formyl-N^Ε-CBZ-L-lysine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-formyl-N^Ε-CBZ-L-lysine

There total 5 articles about N^α-formyl-N^Ε-CBZ-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

formic acid (64-18-6) + N6-[(benzyloxy)carbonyl]-L-lysine (1155-64-2,57705-97-2,67178-46-5,25931-47-9) → Nα-formyl-NΕ-CBZ-L-lysine (53917-47-8)

Guidance literature:

With acetic anhydride; In water; at 20 ℃; for 4h;

DOI:10.1021/ja9914240

Reference yield:

fα(Z)εK-OBu-t → Nα-formyl-NΕ-CBZ-L-lysine (53917-47-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

N(ε)-benzoyloxycarbonyl-L-lysine-tert-butyl ester hydrochloride (1426213-63-9) → Nα-formyl-NΕ-CBZ-L-lysine (53917-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / 48 h / 60 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C

With 1H-imidazole; trifluoroacetic acid; In dichloromethane;

upstream raw materials:

formaldehyd

N₆-[(benzyloxy)carbonyl]-L-lysine

formic acid

N(ε)-benzoyloxycarbonyl-L-lysine-tert-butyl ester hydrochloride

Downstream raw materials:

-

-

-

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Refernces

• 1、 Cai, Hongliang,Guengerich, F. Peter. "Mechanism of aqueous decomposition of trichloroethylene oxide". . p. 11656 - 11663. Retrieved 2007/10/03.