(-)-(3R)-6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(((methanesulfonyl)oxy)methyl)indoline

Base Information

Chemical Name:(-)-(3R)-6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(((methanesulfonyl)oxy)methyl)indoline
CAS No.:128049-48-9
Molecular Formula:C₂₂H₂₇NO₆S
Molecular Weight:433.525
Hs Code.:

Synonyms:(-)-(3R)-6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(((methanesulfonyl)oxy)methyl)indoline

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Chemical Property of (-)-(3R)-6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(((methanesulfonyl)oxy)methyl)indoline

Chemical Property:

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Technology Process of (-)-(3R)-6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(((methanesulfonyl)oxy)methyl)indoline

There total 6 articles about (-)-(3R)-6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(((methanesulfonyl)oxy)methyl)indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 128049-46-7
(-)-(3R)-6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(hydroxymethyl)indoline

: 124-63-0
methanesulfonyl chloride

: 128049-48-9
(-)-(3R)-6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(((methanesulfonyl)oxy)methyl)indoline

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1246/cl.1997.11

Reference yield:

: 106014-83-9
2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol

: 128049-48-9
(-)-(3R)-6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(((methanesulfonyl)oxy)methyl)indoline

Guidance literature:: Multi-step reaction with 6 steps

1: porcine pancreatic lipase on Celit, powdered molecular sieves / 3 h

2: 99 percent / triethylamine / CH₂Cl₂

3: H₂, triethylamine / PtO₂ / tetrahydrofuran / 2280 Torr

4: CH₂Cl₂

5: 91 percent / K₂CO₃ / ethanol

6: 93 percent / triethylamine / CH₂Cl₂

With molecular sieve; porcine pancreatic lipase on Celit; hydrogen; potassium carbonate; triethylamine; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1246/cl.1997.11

Reference yield:

: 186144-33-2
Acetic acid (S)-2-(4-benzyloxy-2-nitro-phenyl)-3-methanesulfonyloxy-propyl ester

: 128049-48-9
(-)-(3R)-6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(((methanesulfonyl)oxy)methyl)indoline

Guidance literature:: Multi-step reaction with 4 steps

1: H₂, triethylamine / PtO₂ / tetrahydrofuran / 2280 Torr

2: CH₂Cl₂

3: 91 percent / K₂CO₃ / ethanol

4: 93 percent / triethylamine / CH₂Cl₂

With hydrogen; potassium carbonate; triethylamine; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1246/cl.1997.11