3,3-DIMETHYL-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

Base Information

• Chemical Name: 3,3-DIMETHYL-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
• CAS No.: 473838-66-3
• Molecular Formula: C15H19NO3
• Molecular Weight: 261.321
• Mol file: 473838-66-3.mol

Synonyms:3,3-DIMETHYL-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

Chemical Property of 3,3-DIMETHYL-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

Chemical Property:

• PSA: 46.61000
• LogP: 2.56210
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

3,3-Dimethyl-4-oxo-piperidine-1-carboxylicAcidBenzylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3-DIMETHYL-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

There total 4 articles about 3,3-DIMETHYL-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

3,3-dimethylpiperidin-4-one hydrochloride (648921-37-3) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl 3,3-dimethyl-4-oxo-piperidine-1-carboxylate (473838-66-3)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 - 15 ℃; for 12h;

Reference yield: 38.86%

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) + methyl iodide (74-88-4) → benzyl 3,3-dimethyl-4-oxo-piperidine-1-carboxylate (473838-66-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 30 ℃; for 16h; Inert atmosphere;

Reference yield:

tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate (324769-06-4) → benzyl 3,3-dimethyl-4-oxo-piperidine-1-carboxylate (473838-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane; 1,4-dioxane / 16 h / 0 - 20 °C

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;

upstream raw materials:

benzyl 4-oxo-1-piperidinecarboxylate

methyl iodide

tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate

3,3-dimethylpiperidin-4-one hydrochloride

Downstream raw materials:

benzyl 5-bromo-3,3-dimethyl-4-oxopiperidine-1-carboxylate

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