(R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-pentane-1,3-dione

Base Information

Chemical Name:(R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-pentane-1,3-dione
CAS No.:287717-25-3
Molecular Formula:C₂₂H₂₉NO₄S₂
Molecular Weight:435.609
Hs Code.:

Synonyms:(R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-pentane-1,3-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-pentane-1,3-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-pentane-1,3-dione

There total 4 articles about (R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-pentane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 79-03-8
propionyl chloride

: 287717-24-2
(S)-4-Benzyl-3-[4-(2-methyl-[1,3]dithian-2-yl)-butyryl]-oxazolidin-2-one

: 287717-25-3
(R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-pentane-1,3-dione

: Propionic acid (Z)-1-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-(2-methyl-[1,3]dithian-2-yl)-but-1-enyl ester

Guidance literature:: (S)-4-Benzyl-3-[4-(2-methyl-[1,3]dithian-2-yl)-butyryl]-oxazolidin-2-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1.5h;

propionyl chloride; In tetrahydrofuran; at -78 ℃; for 0.166667h; Further stages.;
DOI:10.1021/ja020091v

Reference yield: 72.0%

: 79-03-8
propionyl chloride

: 287717-24-2
(S)-4-Benzyl-3-[4-(2-methyl-[1,3]dithian-2-yl)-butyryl]-oxazolidin-2-one

: Propionic acid (Z)-4-(2-methyl-[1,3]dithian-2-yl)-1-(2-oxo-oxazolidin-3-yl)-but-1-enyl ester

: 287717-25-3
(R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-pentane-1,3-dione

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(00)00504-9

Reference yield:

: 134916-00-0
(4S)-4-benzyl-3-(hex-5-enoyl)-1,3-oxazolidin-2-one

: 287717-25-3
(R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-pentane-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 77 percent / O₂; copper (I) chloride; palladium (II) chloride / dimethylformamide; H₂O

2.1: 98 percent / p-toluenesulfonic acid / acetic acid / 0.5 h

3.1: LDA / tetrahydrofuran / 1.5 h / -78 °C

3.2: 72 percent / tetrahydrofuran / 0.17 h / -78 °C

With oxygen; toluene-4-sulfonic acid; copper(l) chloride; palladium dichloride; lithium diisopropyl amide; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide; 1.1: Wacker oxidation;
DOI:10.1021/ja020091v