8-(furan-2-yl)-1-methyl-5-(4-phenylpiperazin-1-yl)-1H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

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Chemical Name:8-(furan-2-yl)-1-methyl-5-(4-phenylpiperazin-1-yl)-1H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine
CAS No.:1357086-91-9
Molecular Formula:C₂₁H₂₀N₈O
Molecular Weight:400.443
Hs Code.:

Synonyms:8-(furan-2-yl)-1-methyl-5-(4-phenylpiperazin-1-yl)-1H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

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Chemical Property of 8-(furan-2-yl)-1-methyl-5-(4-phenylpiperazin-1-yl)-1H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

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Technology Process of 8-(furan-2-yl)-1-methyl-5-(4-phenylpiperazin-1-yl)-1H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

There total 6 articles about 8-(furan-2-yl)-1-methyl-5-(4-phenylpiperazin-1-yl)-1H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 92-54-6
4-phenyl-1-piperazine

: 1357087-42-3
5-chloro-8-(furan-2-yl)-1-methyl-1H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

: 1357086-91-9
8-(furan-2-yl)-1-methyl-5-(4-phenylpiperazin-1-yl)-1H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

Guidance literature:: In ethyl methyl ether; at 100 ℃; for 3h; Autoclave;
DOI:10.1016/j.bmc.2011.11.037

Reference yield:

: 83824-38-8
1-methyl-1H-pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)-dione

: 1357086-91-9
8-(furan-2-yl)-1-methyl-5-(4-phenylpiperazin-1-yl)-1H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 8 h / 50 - 80 °C / Inert atmosphere

1.2: pH 7

2.1: triethylamine / 1,4-dioxane / 5 h / 80 - 90 °C

3.1: N,O-bis-(trimethylsilyl)-acetamide; 1,1,1,3,3,3-hexamethyl-disilazane / 18 h / 120 °C

4.1: ethyl methyl ether / 3 h / 100 °C / Autoclave

With N,O-bis-(trimethylsilyl)-acetamide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; trichlorophosphate; In 1,4-dioxane; ethyl methyl ether; 3.1: Dimroth rearrangement;
DOI:10.1016/j.bmc.2011.11.037

Reference yield:

: 939979-32-5
5,7-dichloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine

: 1357086-91-9
8-(furan-2-yl)-1-methyl-5-(4-phenylpiperazin-1-yl)-1H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 1,4-dioxane / 5 h / 80 - 90 °C

2: N,O-bis-(trimethylsilyl)-acetamide; 1,1,1,3,3,3-hexamethyl-disilazane / 18 h / 120 °C

3: ethyl methyl ether / 3 h / 100 °C / Autoclave

With N,O-bis-(trimethylsilyl)-acetamide; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In 1,4-dioxane; ethyl methyl ether; 2: Dimroth rearrangement;
DOI:10.1016/j.bmc.2011.11.037