2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-<(N,N-dimethylamino)methyl>-1H-benzimidazole

Base Information

Chemical Name:2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-<(N,N-dimethylamino)methyl>-1H-benzimidazole
CAS No.:136304-82-0
Molecular Formula:C₂₈H₃₀N₄
Molecular Weight:422.573
Hs Code.:

Synonyms:2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-<(N,N-dimethylamino)methyl>-1H-benzimidazole

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Chemical Property of 2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-<(N,N-dimethylamino)methyl>-1H-benzimidazole

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Technology Process of 2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-<(N,N-dimethylamino)methyl>-1H-benzimidazole

There total 9 articles about 2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-<(N,N-dimethylamino)methyl>-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 124-40-3
dimethyl amine

: 136285-72-8
2-butyl-7-(chloromethyl)-1-<(2'-cyanobiphenyl-4-yl)methyl>-1H-benzimidazole

: 136304-82-0
2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-<(N,N-dimethylamino)methyl>-1H-benzimidazole

Guidance literature:: In ethanol; water; at 80 ℃; for 4.5h;
DOI:10.1021/jm00064a011

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 136304-82-0
2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-<(N,N-dimethylamino)methyl>-1H-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / K₂CO₃ / dimethylformamide / 15 h / Ambient temperature

2: 90 percent / iron, conc. hydrochloric acid / methanol / 8 h / Heating

3: 93 percent / NaBH₄, / methanol; tetrahydrofuran / 27 h / Heating

4: 92 percent / SO₂Cl, DMF / CHCl₃ / 1 h / Heating

5: 63 percent / H₂O; ethanol / 4.5 h / 80 °C

With hydrogenchloride; sodium tetrahydroborate; sulfuryl dichloride; iron; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00064a011

Reference yield:

: 136304-94-4
methyl 2-(valerylamino)benzoate

: 136304-82-0
2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-<(N,N-dimethylamino)methyl>-1H-benzimidazole

Guidance literature:: Multi-step reaction with 6 steps

1: 28 percent / fuming nitric acid, acetic anhydride, conc. sulfuric acid / 4 h / Ambient temperature

2: 78 percent / K₂CO₃ / dimethylformamide / 15 h / Ambient temperature

3: 90 percent / iron, conc. hydrochloric acid / methanol / 8 h / Heating

4: 93 percent / NaBH₄, / methanol; tetrahydrofuran / 27 h / Heating

5: 92 percent / SO₂Cl, DMF / CHCl₃ / 1 h / Heating

6: 63 percent / H₂O; ethanol / 4.5 h / 80 °C

With hydrogenchloride; sodium tetrahydroborate; sulfuryl dichloride; sulfuric acid; nitric acid; acetic anhydride; iron; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00064a011