2-Nitro-6-pyrimidin-2-yl-4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenylamine

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Chemical Name:2-Nitro-6-pyrimidin-2-yl-4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenylamine
CAS No.:797047-20-2
Molecular Formula:C₁₆H₁₉BN₄O₄
Molecular Weight:342.162
Hs Code.:

Synonyms:2-Nitro-6-pyrimidin-2-yl-4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenylamine

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Chemical Property of 2-Nitro-6-pyrimidin-2-yl-4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenylamine

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Technology Process of 2-Nitro-6-pyrimidin-2-yl-4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenylamine

There total 3 articles about 2-Nitro-6-pyrimidin-2-yl-4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 797047-19-9
4-bromo-2-nitro-6-(pyrimidin-2-yl)benzenamine

: 73183-34-3
bis(pinacol)diborane

: 797047-20-2
2-Nitro-6-pyrimidin-2-yl-4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenylamine

Guidance literature:: With potassium acetate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 105 ℃; for 2.5h;

Reference yield:

: 1073354-10-5
2,2-dimethyl-N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propionamide

: 797047-20-2
2-Nitro-6-pyrimidin-2-yl-4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 100 °C

2.1: bromine; sodium acetate / acetic acid

2.3: Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium acetate; sodium acetate; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; water; acetic acid;
DOI:10.1016/j.bmcl.2014.03.022

Reference yield:

: 797047-16-6
2,2-dimethyl-N-(2-pyrimidin-2-yl-phenyl)-propionamide

: 797047-20-2
2-Nitro-6-pyrimidin-2-yl-4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: bromine; sodium acetate / acetic acid

1.3: Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium acetate; sodium acetate; In 1,4-dioxane; acetic acid;
DOI:10.1016/j.bmcl.2014.03.022