2-Hydroxy-6-methyl-3-trifluoromethanesulfonyloxy-4-[2-(1,6,8-trimethoxy-9,10-dioxo-3-trifluoromethanesulfonyloxy-9,10-dihydro-anthracen-2-yl)-ethyl]-benzoic acid methyl ester

Base Information

• Chemical Name: 2-Hydroxy-6-methyl-3-trifluoromethanesulfonyloxy-4-[2-(1,6,8-trimethoxy-9,10-dioxo-3-trifluoromethanesulfonyloxy-9,10-dihydro-anthracen-2-yl)-ethyl]-benzoic acid methyl ester
• CAS No.: 149913-08-6
• Molecular Formula: C₃₀H₂₄F₆O₁₄S₂
• Molecular Weight: 786.635
• Mol file: 149913-08-6.mol

Synonyms:2-Hydroxy-6-methyl-3-trifluoromethanesulfonyloxy-4-[2-(1,6,8-trimethoxy-9,10-dioxo-3-trifluoromethanesulfonyloxy-9,10-dihydro-anthracen-2-yl)-ethyl]-benzoic acid methyl ester

Chemical Property of 2-Hydroxy-6-methyl-3-trifluoromethanesulfonyloxy-4-[2-(1,6,8-trimethoxy-9,10-dioxo-3-trifluoromethanesulfonyloxy-9,10-dihydro-anthracen-2-yl)-ethyl]-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Hydroxy-6-methyl-3-trifluoromethanesulfonyloxy-4-[2-(1,6,8-trimethoxy-9,10-dioxo-3-trifluoromethanesulfonyloxy-9,10-dihydro-anthracen-2-yl)-ethyl]-benzoic acid methyl ester

There total 11 articles about 2-Hydroxy-6-methyl-3-trifluoromethanesulfonyloxy-4-[2-(1,6,8-trimethoxy-9,10-dioxo-3-trifluoromethanesulfonyloxy-9,10-dihydro-anthracen-2-yl)-ethyl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + Trifluoro-methanesulfonic acid 5-methyl-4-oxo-2-phenyl-2-o-tolyl-7-[2-(1,6,8-trimethoxy-9,10-dioxo-3-trifluoromethanesulfonyloxy-9,10-dihydro-anthracen-2-yl)-ethyl]-4H-benzo[1,3]dioxin-8-yl ester (149913-01-9) → 2-Hydroxy-6-methyl-3-trifluoromethanesulfonyloxy-4-[2-(1,6,8-trimethoxy-9,10-dioxo-3-trifluoromethanesulfonyloxy-9,10-dihydro-anthracen-2-yl)-ethyl]-benzoic acid methyl ester (149913-08-6)

Guidance literature:

With sulfuric acid;

Reference yield:

8-Hydroxy-5-methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxin-4-one (149912-98-1) → 2-Hydroxy-6-methyl-3-trifluoromethanesulfonyloxy-4-[2-(1,6,8-trimethoxy-9,10-dioxo-3-trifluoromethanesulfonyloxy-9,10-dihydro-anthracen-2-yl)-ethyl]-benzoic acid methyl ester (149913-08-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 99 percent / ICl, Et₃N

2: 95 percent

3: 95 percent / Pd(CF₃COO)2, P(C₆H₅)3, i-Pr₂NH, CF₃COOAg / tetrahydrofuran / 90 °C

4: 77 percent / Zn, conc. aq. HCl, N-methylpyrrolidinone

5: 92 percent / H₂SO₄

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; palladium(II) trifluoroacetate; sulfuric acid; silver trifluoroacetate; Iodine monochloride; triethylamine; diisopropylamine; triphenylphosphine; zinc; In tetrahydrofuran;

Reference yield:

5-Methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxole-4-carboxylic acid (149912-97-0) → 2-Hydroxy-6-methyl-3-trifluoromethanesulfonyloxy-4-[2-(1,6,8-trimethoxy-9,10-dioxo-3-trifluoromethanesulfonyloxy-9,10-dihydro-anthracen-2-yl)-ethyl]-benzoic acid methyl ester (149913-08-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 86 percent / CF₃COOH

2: 99 percent / ICl, Et₃N

3: 95 percent

4: 95 percent / Pd(CF₃COO)2, P(C₆H₅)3, i-Pr₂NH, CF₃COOAg / tetrahydrofuran / 90 °C

5: 77 percent / Zn, conc. aq. HCl, N-methylpyrrolidinone

6: 92 percent / H₂SO₄

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; palladium(II) trifluoroacetate; sulfuric acid; silver trifluoroacetate; Iodine monochloride; triethylamine; diisopropylamine; triphenylphosphine; trifluoroacetic acid; zinc; In tetrahydrofuran;

upstream raw materials:

methanol

Trifluoro-methanesulfonic acid 5-methyl-4-oxo-2-phenyl-2-o-tolyl-7-[2-(1,6,8-trimethoxy-9,10-dioxo-3-trifluoromethanesulfonyloxy-9,10-dihydro-anthracen-2-yl)-ethyl]-4H-benzo[1,3]dioxin-8-yl ester

8-Hydroxy-5-methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxin-4-one

5-Methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxole-4-carboxylic acid

Downstream raw materials:

2-Methoxy-6-methyl-3-trifluoromethanesulfonyloxy-4-[2-(1,6,8-trimethoxy-9,10-dioxo-3-trifluoromethanesulfonyloxy-9,10-dihydro-anthracen-2-yl)-ethyl]-benzoic acid methyl ester

G-2N

G-2A