2-(1-{[5-(benzyloxy)-2-chlorophenyl]carbonyl}piperidin-4-yl)-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

Base Information

Chemical Name:2-(1-{[5-(benzyloxy)-2-chlorophenyl]carbonyl}piperidin-4-yl)-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one
CAS No.:1227152-72-8
Molecular Formula:C₃₂H₃₄ClN₃O₅
Molecular Weight:576.092
Hs Code.:

Synonyms:2-(1-{[5-(benzyloxy)-2-chlorophenyl]carbonyl}piperidin-4-yl)-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

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Chemical Property of 2-(1-{[5-(benzyloxy)-2-chlorophenyl]carbonyl}piperidin-4-yl)-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

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Technology Process of 2-(1-{[5-(benzyloxy)-2-chlorophenyl]carbonyl}piperidin-4-yl)-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

There total 1 articles about 2-(1-{[5-(benzyloxy)-2-chlorophenyl]carbonyl}piperidin-4-yl)-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227152-72-8
2-(1-{[5-(benzyloxy)-2-chlorophenyl]carbonyl}piperidin-4-yl)-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

Guidance literature:

Reference yield:

: 1227152-72-8
2-(1-{[5-(benzyloxy)-2-chlorophenyl]carbonyl}piperidin-4-yl)-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

: 105-36-2
ethyl bromoacetate

: 1227152-78-4
ethyl [4-chloro-3-({4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}carbonyl)phenoxy]acetate

Guidance literature:: 2-(1-{[5-(benzyloxy)-2-chlorophenyl]carbonyl}piperidin-4-yl)-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one; With ammonium formate; palladium 10% on activated carbon; In methanol; Inert atmosphere; Reflux;

ethyl bromoacetate; With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere;

Reference yield:

: 1227152-72-8
2-(1-{[5-(benzyloxy)-2-chlorophenyl]carbonyl}piperidin-4-yl)-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

: 75-03-6
ethyl iodide

: 1227153-71-0
2-{1-[(2-chloro-5-ethoxyphenyl)carbonyl]piperidin-4-yl}-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

Guidance literature:: 2-(1-{[5-(benzyloxy)-2-chlorophenyl]carbonyl}piperidin-4-yl)-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one; With ammonium formate; palladium 10% on activated carbon; In methanol; Inert atmosphere; Reflux;

ethyl iodide; With potassium carbonate; In dimethyl sulfoxide; at 55 ℃; for 3.5h; Inert atmosphere;