metronidazole 4-phenyl-1-piperazinoacetate

Base Information

Chemical Name:metronidazole 4-phenyl-1-piperazinoacetate
CAS No.:370097-67-9
Molecular Formula:C₁₈H₂₃N₅O₄
Molecular Weight:373.412
Hs Code.:

Synonyms:metronidazole 4-phenyl-1-piperazinoacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of metronidazole 4-phenyl-1-piperazinoacetate

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Technology Process of metronidazole 4-phenyl-1-piperazinoacetate

There total 2 articles about metronidazole 4-phenyl-1-piperazinoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 92-54-6
4-phenyl-1-piperazine

: 90102-74-2
chloroacetic acid 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester

: 370097-67-9
metronidazole 4-phenyl-1-piperazinoacetate

Guidance literature:: In 1,4-dioxane; at 20 ℃; for 24h;
DOI:10.1211/0022357011776199

Reference yield:

: 443-48-1
metronidazole

: 370097-67-9
metronidazole 4-phenyl-1-piperazinoacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / pyridine / CH₂Cl₂ / 2 h / Heating

2: 85 percent / dioxane / 24 h / 20 °C

With pyridine; In 1,4-dioxane; dichloromethane;
DOI:10.1211/0022357011776199