Technology Process of 6-Quinoxalinamine,3,7-dimethyl-(9CI)
There total 6 articles about 6-Quinoxalinamine,3,7-dimethyl-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
nickel;
In
ethanol; water;
for 1h;
under 760 Torr;
Ambient temperature;
DOI:10.1016/0040-4020(89)80127-9
- Guidance literature:
-
4-nitro-5-chloro-1,2-phenylenediamine; 2-oxopropanal;
With
iron; ammonium chloride;
In
ethanol;
at 17 - 25 ℃;
for 1h;
Reflux;
Inert atmosphere;
Trimethylboroxine;
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate;
In
1,4-dioxane; water;
at 17 - 25 ℃;
for 2h;
Reflux;
Inert atmosphere;
With
iron; ammonium chloride;
In
ethanol; water;
at 17 - 100 ℃;
for 1h;
Overall yield = 81 percent; Overall yield = 600 mg;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 89 percent / Et3N / ethanol / 4 h / Heating
2: 65 percent / hydrazine hydrate / Raney-Ni / ethanol; 1,2-dichloro-ethane / 4 h / 60 °C
3: 78 percent / tetrakis(acetonitrile)copper(I) tetrafluoroborate / toluene / 20 h / 90 °C
4: 90 percent / H2 / Raney-Ni / ethanol; H2O / 1 h / 760 Torr / Ambient temperature
With
hydrogen; tetrakis(acetonitrile)copper(I) tetrafluoroborate; hydrazine hydrate; triethylamine;
nickel;
In
ethanol; water; 1,2-dichloro-ethane; toluene;
DOI:10.1016/0040-4020(89)80127-9
