4,4,5,5-tetramethyl-2-(1-phenylpropan-2-yl)-1,3,2-dioxaborolane

Base Information

• Chemical Name: 4,4,5,5-tetramethyl-2-(1-phenylpropan-2-yl)-1,3,2-dioxaborolane
• CAS No.: 916658-74-7
• Molecular Formula: C₁₅H₂₃BO₂
• Molecular Weight: 246.157
• Mol file: 916658-74-7.mol

Synonyms:4,4,5,5-tetramethyl-2-(1-phenylpropan-2-yl)-1,3,2-dioxaborolane

Chemical Property of 4,4,5,5-tetramethyl-2-(1-phenylpropan-2-yl)-1,3,2-dioxaborolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4,5,5-tetramethyl-2-(1-phenylpropan-2-yl)-1,3,2-dioxaborolane

There total 35 articles about 4,4,5,5-tetramethyl-2-(1-phenylpropan-2-yl)-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

allylbenzene (300-57-2,57807-91-7) + bis(pinacol)diborane (73183-34-3) → 4,4,5,5-tetramethyl-2-(1-phenylpropan-2-yl)-1,3,2-dioxaborolane (916658-74-7)

Guidance literature:

With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); potassium tert-butylate; In methanol; acetonitrile; at 20 ℃; for 2h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.6b03090

Reference yield: 97.3%

1-propenylbenzene (873-66-5) + bis(pinacol)diborane (73183-34-3) → 4,4,5,5-tetramethyl-2-(1-phenylpropan-2-yl)-1,3,2-dioxaborolane (916658-74-7)

Guidance literature:

bis(pinacol)diborane; With CuCl(SIMes); sodium t-butanolate; In toluene; for 0.166667h; Inert atmosphere;

1-propenylbenzene; With methanol; In toluene; at 22 ℃; for 0.166667h; regioselective reaction; Inert atmosphere;

Reference yield: 95.0%

1-phenylpropene (637-50-3) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 4,4,5,5-tetramethyl-2-(1-phenyl-propyl)-[1,3,2]dioxaborolane (916658-71-4) + 4,4,5,5-tetramethyl-2-(1-phenylpropan-2-yl)-1,3,2-dioxaborolane (916658-74-7) + 4,4,5,5-tetramethyl-2-(3-phenylpropyl)-[1,3,2]dioxaborolane (329685-40-7)

Guidance literature:

[(η4-1,5-cyclooctadiene)Rh(κ2-P,N-3-P(i)Pr2-2-NMe2-indenide)]; In tetrahydrofuran-d8; THF-d8, room temp., 2 mol% of catalyst, 72 h; detected by NMR spectra;

DOI:10.1021/om060742m

upstream raw materials:

1-phenylpropene

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

2,3-dimethyl-2,3-butane diol

methanol

Downstream raw materials:

(R)-1-phenyl-propan-2-ol

2-amino-1-phenylpropane

(S)-1-phenylpropan-2-ol