2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}-5-(L-phenylalanylamino)valeric acid

Base Information

Chemical Name:2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}-5-(L-phenylalanylamino)valeric acid
CAS No.:1335138-64-1
Molecular Formula:C₂₅H₃₆N₄O₃
Molecular Weight:440.586
Hs Code.:

Synonyms:2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}-5-(L-phenylalanylamino)valeric acid

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Chemical Property of 2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}-5-(L-phenylalanylamino)valeric acid

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Technology Process of 2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}-5-(L-phenylalanylamino)valeric acid

There total 12 articles about 2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}-5-(L-phenylalanylamino)valeric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335139-76-8
benzyl 5-({N-[(benzyloxy)carbonyl]-L-phenylalanyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

: 1335138-64-1
2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}-5-(L-phenylalanylamino)valeric acid

Guidance literature:: With palladium 10% on activated carbon; water; hydrogen; In ethanol; at 20 ℃; for 5h; under 760.051 Torr;

Reference yield:

: 1335144-16-5
5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

: 1335138-64-1
2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}-5-(L-phenylalanylamino)valeric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 18 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

3: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; triethylamine / N,N-dimethyl-formamide / 72 h / 20 °C

4: palladium 10% on activated carbon; hydrogen; water / ethanol / 5 h / 20 °C / 760.05 Torr

With hydrogenchloride; dmap; palladium 10% on activated carbon; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1335139-75-7
benzyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

: 1335138-64-1
2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}-5-(L-phenylalanylamino)valeric acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

2: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; triethylamine / N,N-dimethyl-formamide / 72 h / 20 °C

3: palladium 10% on activated carbon; hydrogen; water / ethanol / 5 h / 20 °C / 760.05 Torr

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;