5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Base Information

Chemical Name:5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid
CAS No.:1335144-16-5
Molecular Formula:C₂₁H₃₅N₃O₄
Molecular Weight:393.527
Hs Code.:

Synonyms:5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

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Chemical Property of 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Chemical Property:

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Technology Process of 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

There total 9 articles about 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335144-15-4
methyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

: 1335144-16-5
5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: 1335139-07-5
dimethyl 2-(3-((tert-butoxycarbonyl)amino)propyl)malonate

: 1335144-16-5
5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide monohydrate / methanol; water / 15 h / 0 - 20 °C

2: piperidine; propionic acid / cyclohexane / 48 h / Reflux

3: palladium 10% on activated carbon; hydrogen; water / ethanol / 6.5 h / 20 - 60 °C / 760.05 Torr

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

With piperidine; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; propionic acid; In tetrahydrofuran; methanol; ethanol; cyclohexane; water; 2: |Knoevenagel Condensation;

Reference yield:

: 1335139-08-6
1-(trans-4-methylcyclohexyl)-1H-imidazole-4-carbaldehyde

: 1335144-16-5
5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine; propionic acid / cyclohexane / 48 h / Reflux

2: palladium 10% on activated carbon; hydrogen; water / ethanol / 6.5 h / 20 - 60 °C / 760.05 Torr

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

With piperidine; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; propionic acid; In tetrahydrofuran; ethanol; cyclohexane; water; 1: |Knoevenagel Condensation;