benzyl 5-({N-[(benzyloxy)carbonyl]-L-phenylalanyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Base Information

Chemical Name:benzyl 5-({N-[(benzyloxy)carbonyl]-L-phenylalanyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate
CAS No.:1335139-76-8
Molecular Formula:C₄₀H₄₈N₄O₅
Molecular Weight:664.845
Hs Code.:

Synonyms:benzyl 5-({N-[(benzyloxy)carbonyl]-L-phenylalanyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

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Chemical Property of benzyl 5-({N-[(benzyloxy)carbonyl]-L-phenylalanyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

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Technology Process of benzyl 5-({N-[(benzyloxy)carbonyl]-L-phenylalanyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

There total 11 articles about benzyl 5-({N-[(benzyloxy)carbonyl]-L-phenylalanyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 1335138-63-0
benzyl 5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate hydrochloride

: 1335139-76-8
benzyl 5-({N-[(benzyloxy)carbonyl]-L-phenylalanyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Guidance literature:: With triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

: 1335144-16-5
5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

: 1335139-76-8
benzyl 5-({N-[(benzyloxy)carbonyl]-L-phenylalanyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 18 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

3: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; triethylamine / N,N-dimethyl-formamide / 72 h / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1335139-75-7
benzyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

: 1335139-76-8
benzyl 5-({N-[(benzyloxy)carbonyl]-L-phenylalanyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

2: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; triethylamine / N,N-dimethyl-formamide / 72 h / 20 °C

With hydrogenchloride; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In 1,4-dioxane; N,N-dimethyl-formamide;