benzyl 5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate hydrochloride

Base Information

Chemical Name:benzyl 5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate hydrochloride
CAS No.:1335138-63-0
Molecular Formula:C₂₃H₃₃N₃O₂*ClH
Molecular Weight:419.995
Hs Code.:

Synonyms:benzyl 5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate hydrochloride

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Chemical Property of benzyl 5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate hydrochloride

Chemical Property:

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Technology Process of benzyl 5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate hydrochloride

There total 10 articles about benzyl 5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335139-75-7
benzyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

: 1335138-63-0
benzyl 5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 24h;

Reference yield:

: 1335144-16-5
5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

: 1335138-63-0
benzyl 5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 18 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1335139-07-5
dimethyl 2-(3-((tert-butoxycarbonyl)amino)propyl)malonate

: 1335138-63-0
benzyl 5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hydroxide monohydrate / methanol; water / 15 h / 0 - 20 °C

2: piperidine; propionic acid / cyclohexane / 48 h / Reflux

3: palladium 10% on activated carbon; hydrogen; water / ethanol / 6.5 h / 20 - 60 °C / 760.05 Torr

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 18 h / 20 °C

6: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

With piperidine; hydrogenchloride; dmap; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; propionic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; cyclohexane; water; 2: |Knoevenagel Condensation;