2,2-Dimethyl-propionic acid (2E,6E)-(4R,5R)-7-iodo-2,4,6-trimethyl-5-triphenylsilanyloxy-hepta-2,6-dienyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (2E,6E)-(4R,5R)-7-iodo-2,4,6-trimethyl-5-triphenylsilanyloxy-hepta-2,6-dienyl ester
CAS No.:361524-99-4
Molecular Formula:C₃₃H₃₉IO₃Si
Molecular Weight:638.661
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (2E,6E)-(4R,5R)-7-iodo-2,4,6-trimethyl-5-triphenylsilanyloxy-hepta-2,6-dienyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (2E,6E)-(4R,5R)-7-iodo-2,4,6-trimethyl-5-triphenylsilanyloxy-hepta-2,6-dienyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (2E,6E)-(4R,5R)-7-iodo-2,4,6-trimethyl-5-triphenylsilanyloxy-hepta-2,6-dienyl ester

There total 7 articles about 2,2-Dimethyl-propionic acid (2E,6E)-(4R,5R)-7-iodo-2,4,6-trimethyl-5-triphenylsilanyloxy-hepta-2,6-dienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3282-30-2
pivaloyl chloride

: 361525-04-4
(2E,4R,5R,6E)-2,4,6-trimethyl-5-(triphenylsiloxy)-7-iodo-2,6-heptadien-1-ol

: 361524-99-4
2,2-Dimethyl-propionic acid (2E,6E)-(4R,5R)-7-iodo-2,4,6-trimethyl-5-triphenylsilanyloxy-hepta-2,6-dienyl ester

Guidance literature:: With pyridine; dmap;
DOI:10.1021/jo0158128

Reference yield:

: (E)-3-Hydroxy-5-iodo-2,4-dimethyl-pent-4-enoic acid phenyl ester

: 361524-99-4
2,2-Dimethyl-propionic acid (2E,6E)-(4R,5R)-7-iodo-2,4,6-trimethyl-5-triphenylsilanyloxy-hepta-2,6-dienyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole / dimethylformamide / 20 °C

2: DIBAL / CH₂Cl₂ / -78 °C

3: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

4: tetrahydrofuran / Heating

5: 95 percent / DIBAL / CH₂Cl₂ / -78 °C

6: 90 percent / DMAP; pyridine

With pyridine; 1H-imidazole; dmap; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 4: Wittig reaction;
DOI:10.1021/jo0158128

Reference yield:

: 76-86-8
Triphenylsilyl chloride

: 361524-99-4
2,2-Dimethyl-propionic acid (2E,6E)-(4R,5R)-7-iodo-2,4,6-trimethyl-5-triphenylsilanyloxy-hepta-2,6-dienyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole / dimethylformamide / 20 °C

2: DIBAL / CH₂Cl₂ / -78 °C

3: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

4: tetrahydrofuran / Heating

5: 95 percent / DIBAL / CH₂Cl₂ / -78 °C

6: 90 percent / DMAP; pyridine

With pyridine; 1H-imidazole; dmap; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 4: Wittig reaction;
DOI:10.1021/jo0158128