DIETHYL 1-(2-BROMO-ETHYL)-1H-PYRAZOLE-3,5-DICARBOXYLIC ACID

Base Information

• Chemical Name: DIETHYL 1-(2-BROMO-ETHYL)-1H-PYRAZOLE-3,5-DICARBOXYLIC ACID
• CAS No.: 131727-29-2
• Molecular Formula: C11H15BrN2O4
• Molecular Weight: 319.155
• Hs Code.: 2933199090
• Mol file: 131727-29-2.mol

Synonyms:DIETHYL 1-(2-BROMO-ETHYL)-1H-PYRAZOLE-3,5-DICARBOXYLIC ACID

Chemical Property of DIETHYL 1-(2-BROMO-ETHYL)-1H-PYRAZOLE-3,5-DICARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.83E-06mmHg at 25°C
• Refractive Index: 1.558
• Boiling Point: 395.5°C at 760 mmHg
• Flash Point: 193°C
• PSA: 70.42000
• Density: 1.48g/cm³
• LogP: 1.63140

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Diethyl1-(2-bromoethyl)-1H-pyrazole-3,5-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIETHYL 1-(2-BROMO-ETHYL)-1H-PYRAZOLE-3,5-DICARBOXYLIC ACID

There total 2 articles about DIETHYL 1-(2-BROMO-ETHYL)-1H-PYRAZOLE-3,5-DICARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethylene dibromide (106-93-4) + diethyl 1H-pyrazole-3,5-dicarboxylate (37687-24-4) → 1-(2-bromoethyl)-1H-pyrazole-3,5-dicarboxylic acid diethyl ester (131727-29-2)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux;

DOI:10.1016/j.bmcl.2017.05.081

Reference yield: 76.0%

2-bromoethanol (540-51-2) + diethyl 1H-pyrazole-3,5-dicarboxylate (37687-24-4) → 1-(2-bromoethyl)-1H-pyrazole-3,5-dicarboxylic acid diethyl ester (131727-29-2)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 1.5h;

Reference yield: 68.0%

1-(2-bromoethyl)-1H-pyrazole-3,5-dicarboxylic acid diethyl ester (131727-29-2) + methyl 4-[N-(1-oxopropyl)-N-phenylamino]-4-piperidinecarboxylate (72996-78-2) → N-(phenyl)-N-[1-(2-(3,5-diethoxycarbonyl-1H-pyrazol-1-yl)ethyl)-4-methoxycarbonyl-4-piperidinyl]-propanamide (131727-27-0)

Guidance literature:

With sodium carbonate; sodium iodide; In acetonitrile; Heating;

DOI:10.1021/jm00106a051

upstream raw materials:

ethylene dibromide

diethyl 1H-pyrazole-3,5-dicarboxylate

2-bromoethanol

Downstream raw materials:

N-(phenyl)-N-[1-(2-(3,5-diethoxycarbonyl-1H-pyrazol-1-yl)ethyl)-4-methoxycarbonyl-4-piperidinyl]-propanamide

5-[2-(4-dimethylaminomethyl-phenyl)-ethyl]-4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester

5-[2-(4-diethylaminomethyl-phenyl)-ethyl]-4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester

4-oxo-5-[2-(4-piperidin-1-ylmethyl-phenyl)-ethyl]-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester