Ethyl 2-amino-1-cyano-5,6,7,8-tetrahydroindolizine-3-carboxylate

Base Information

Chemical Name:Ethyl 2-amino-1-cyano-5,6,7,8-tetrahydroindolizine-3-carboxylate
CAS No.:132994-04-8
Molecular Formula:C12H15N3O2
Molecular Weight:233.27
Hs Code.:2933990090
DSSTox Substance ID:DTXSID20353444
Wikidata:Q82131046
ChEMBL ID:CHEMBL1607348
Mol file:132994-04-8.mol

Synonyms:ethyl 2-amino-1-cyano-5,6,7,8-tetrahydroindolizine-3-carboxylate;132994-04-8;Oprea1_816291;MLS000533749;SCHEMBL6819330;CHEMBL1607348;DTXSID20353444;HMS2288G21;STK833081;AKOS001642875;ETHYL2-AMINO-1-CYANO-5,6,7,8-TETRAHYDROINDOLIZINE-3-CARBOXYLATE;AB09207;SMR000141187;EU-0010551;EN300-18581268;SR-01000484190;SR-01000484190-1;ethyl 2-amino-1-cyano-5,6,7,8-tetrahydro-3-indolizinecarboxylate

Suppliers and Price of Ethyl 2-amino-1-cyano-5,6,7,8-tetrahydroindolizine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ETHYL 2-AMINO-1-CYANO-5,6,7,8-TETRAHYDROINDOLIZINE-3-CARBOXYLATE 95.00%
5MG
$ 499.09

Total 3 raw suppliers

Chemical Property of Ethyl 2-amino-1-cyano-5,6,7,8-tetrahydroindolizine-3-carboxylate

Chemical Property:

PSA：81.04000
LogP:2.03618
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:233.116426730
Heavy Atom Count:17
Complexity:349

Purity/Quality:

98%min ^*data from raw suppliers

ETHYL 2-AMINO-1-CYANO-5,6,7,8-TETRAHYDROINDOLIZINE-3-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(C(=C2N1CCCC2)C#N)N

Technology Process of Ethyl 2-amino-1-cyano-5,6,7,8-tetrahydroindolizine-3-carboxylate

There total 5 articles about Ethyl 2-amino-1-cyano-5,6,7,8-tetrahydroindolizine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 78807-02-0
2-dicyanomethylidene-2,3,4,5-tetrahydro-1H,6H-pyridine

: 105-36-2
ethyl bromoacetate

: 132994-04-8
ethyl 2-amino-1-cyano-5,6,7,8-tetrahydroindolizine-3-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 5h;
DOI:10.1021/acs.jmedchem.5b01644

Reference yield:

: 5693-62-9
2,3,4,5-tetrahydro-6-methoxypyridine

: 132994-04-8
ethyl 2-amino-1-cyano-5,6,7,8-tetrahydroindolizine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 1 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 100 °C

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b01644