Technology Process of 3-Quinolinamine,1,2,3,4-tetrahydro-,(R)-(9CI)
There total 11 articles about 3-Quinolinamine,1,2,3,4-tetrahydro-,(R)-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-aminoquinoline;
With
H2SiEt2; tris(pentafluorophenyl)borate;
In
chloroform;
at 100 ℃;
for 24h;
Inert atmosphere;
With
hydrogenchloride;
In
diethyl ether;
at 20 ℃;
for 1h;
DOI:10.1055/s-0036-1588442
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; dichloromethane / 24 h / 20 °C
2: bis-[(trifluoroacetoxy)iodo]benzene; trifluoroacetic acid / dichloromethane / 1.17 h / 0 °C
3: hydrogen; palladium 10% on activated carbon / ethanol / 2585.81 Torr
4: dimethyl sulfide borane / tetrahydrofuran / 120 h / 0 - 20 °C / Reflux
With
palladium 10% on activated carbon; hydrogen; dimethyl sulfide borane; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene;
In
tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/acs.jmedchem.5b01612
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 40 ℃;
for 2h;
