2-(BIS-(2-PYRIDYLMETHYL)-AMINO)-ETHANOL

Base Information

• Chemical Name: 2-(BIS-(2-PYRIDYLMETHYL)-AMINO)-ETHANOL
• CAS No.: 149860-22-0
• Molecular Formula: C14H17 N3 O
• Molecular Weight: 243.308
• Mol file: 149860-22-0.mol

Synonyms:(2-Hydroxyethyl)bis(2-pyridylmethyl)amine;N,N-Bis(2-pyridylmethyl)-2-hydroxyethylamine; N,N-Bis(pyrid-2-ylmethyl)-N-(2-hydroxyethyl)amine;N,N-Dipicolylaminoethanol; NSC 371721

Chemical Property of 2-(BIS-(2-PYRIDYLMETHYL)-AMINO)-ETHANOL

Chemical Property:

• Vapor Pressure: 1.62E-06mmHg at 25°C
• Refractive Index: 1.601
• Boiling Point: 382°C at 760 mmHg
• Flash Point: 184.8°C
• PSA: 49.25000
• Density: 1.174g/cm³
• LogP: 1.47110

Purity/Quality:

97% ^*data from raw suppliers

2-(Bis-(2-pyridyl-methyl)-amino)-ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(BIS-(2-PYRIDYLMETHYL)-AMINO)-ETHANOL

There total 7 articles about 2-(BIS-(2-PYRIDYLMETHYL)-AMINO)-ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

pyridine-2-carbaldehyde (1121-60-4) + ethanolamine (141-43-5) → N,N,-bis(2-pyridylmethyl)-N-(2-hydroxyethyl)amine (149860-22-0)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; for 4h;

DOI:10.1039/c5dt01041a

Reference yield: 90.0%

bis[(2-pyridyl)methyl]amine (1539-42-0) + 2-chloro-ethanol (107-07-3) → N,N,-bis(2-pyridylmethyl)-N-(2-hydroxyethyl)amine (149860-22-0)

Guidance literature:

In toluene; for 6h; Reflux;

Reference yield: 78.2%

2-[N,N-bis(2-pyridylmethyl)amino]ethyl acetate (1167995-27-8) → N,N,-bis(2-pyridylmethyl)-N-(2-hydroxyethyl)amine (149860-22-0)

Guidance literature:

With methanol; sodium hydroxide; at 20 ℃; for 2.5h;

upstream raw materials:

pyridine-2-carbaldehyde

ethanolamine

2-chloromethylpyridine hydrochloride

2-chloromethylpyridine

Downstream raw materials:

N-(2-benzyloxyethyl)-N,N-bis(2-pyridylmethyl)amine

C₂₁H₂₂N₄O₃

Refernces

• 1、 -. "Metal beta-lactamase inhibitor as well as preparation method and application thereof". Paragraph 0053; 0056. . Retrieved 2020/10/14.
• 2、 Ording-Wenker, Erica C. M.,Siegler, Maxime A.,Lutz, Martin,Bouwman, Elisabeth. "Catalytic catechol oxidation by copper complexes: Development of a structure-activity relationship". . p. 12196 - 12209. Retrieved 2016/01/15.