(2-Morpholin-4-yl-phenyl)methanol

Base Information

• Chemical Name: (2-Morpholin-4-yl-phenyl)methanol
• CAS No.: 465514-33-4
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Hs Code.: 2934999090
• European Community (EC) Number: 872-783-4
• DSSTox Substance ID: DTXSID50380187
• Wikidata: Q72493086
• Mol file: 465514-33-4.mol

Synonyms:(2-Morpholin-4-yl-phenyl)methanol;465514-33-4;(2-morpholin-4-ylphenyl)methanol;(2-Morpholinophenyl)methanol;[2-(morpholin-4-yl)phenyl]methanol;2-Morpholinophenylmethanol;Benzenemethanol,2-(4-morpholinyl)-;SCHEMBL1715455;DTXSID50380187;MYGVYNRBQSAMIF-UHFFFAOYSA-N;MFCD03086181;AKOS001452905;AB86693;DS-0145;FS-3025;SDCCGMLS-0066051.P001;(2-morpholinophenyl)methanol, AldrichCPR;AM20050527;CS-0215869;FT-0604643;EN300-30434;A872251;J-500882;Z235361235;JP4

Chemical Property of (2-Morpholin-4-yl-phenyl)methanol

Chemical Property:

• Vapor Pressure: 6.7E-06mmHg at 25°C
• Melting Point: 54 °C
• Refractive Index: 1.568
• Boiling Point: 362.8 °C at 760 mmHg
• PKA: 14.26±0.10(Predicted)
• Flash Point: 173.2 °C
• PSA: 32.70000
• Density: 1.16 g/cm³
• LogP: 1.08050
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 193.110278721
• Heavy Atom Count: 14
• Complexity: 169

Purity/Quality:

97% ^*data from raw suppliers

(2-Morpholin-4-yl-phenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=CC=CC=C2CO

Technology Process of (2-Morpholin-4-yl-phenyl)methanol

There total 3 articles about (2-Morpholin-4-yl-phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

2-(morpholin-4-yl)benzaldehyde (58028-76-5) → (2-morpholin-4-ylphenyl)methanol (465514-33-4)

Guidance literature:

With potassium carbonate; In water; at 200 ℃; for 1h; microwave irradiation;

DOI:10.1016/j.tet.2005.07.046

Reference yield:

methyl 2-morpholinobenzoate (223560-37-0) → (2-morpholin-4-ylphenyl)methanol (465514-33-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm950610n

Reference yield:

methyl 2-fluorobenzoate (394-35-4) → (2-morpholin-4-ylphenyl)methanol (465514-33-4)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / Ambient temperature

2: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm950610n

upstream raw materials:

methyl 2-morpholinobenzoate

2-(morpholin-4-yl)benzaldehyde

methyl 2-fluorobenzoate

Downstream raw materials:

2-morpholinobenzyl chloride

4-[2-(1-Pyridin-2-yl-1H-imidazol-2-ylsulfanylmethyl)-phenyl]-morpholine

4-{2-[1-(3-Methyl-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine

2-(2-Morpholin-4-yl-benzylsulfanyl)-1-pyridin-2-yl-1,4,5,6-tetrahydro-cyclopentaimidazole