methyl 2-morpholinobenzoate

Base Information

• Chemical Name: methyl 2-morpholinobenzoate
• CAS No.: 223560-37-0
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.256
• Hs Code.: 2934999090
• Mol file: 223560-37-0.mol

Synonyms:methyl 2-morpholinobenzoate

Chemical Property of methyl 2-morpholinobenzoate

Chemical Property:

Purity/Quality:

Methyl 2-morpholin-4-ylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-morpholinobenzoate

There total 3 articles about methyl 2-morpholinobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methanol (67-56-1) + N-(quinolin-8-yl)-2-(N-morpholino)benzamide (1531629-04-5) → methyl 2-morpholinobenzoate (223560-37-0)

Guidance literature:

With sodium hydroxide; at 130 ℃; for 24h;

DOI:10.1016/j.jcat.2014.09.015 DOI:10.1016/j.jcat.2014.09.015

Reference yield: 60.0%

C12H19NO3 → methyl 2-morpholinobenzoate (223560-37-0)

Guidance literature:

With copper diacetate; palladium diacetate; In dimethyl sulfoxide; at 60 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2020.151659

Reference yield:

morpholine (110-91-8,99108-56-2) + methyl 2-fluorobenzoate (394-35-4) → methyl 2-morpholinobenzoate (223560-37-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm950610n

upstream raw materials:

morpholine

methyl 2-fluorobenzoate

methanol

N-(quinolin-8-yl)-2-(N-morpholino)benzamide

Downstream raw materials:

(2-morpholin-4-ylphenyl)methanol

2-morpholinobenzyl chloride

4-[2-(1-Pyridin-2-yl-1H-imidazol-2-ylsulfanylmethyl)-phenyl]-morpholine

4-{2-[1-(3-Methyl-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine

Refernces

• 1、 Kishimoto, Ryo,Mikami, Shunya,Okada, Sho,Takabatake, Tetsuhiko,Toyota, Masahiro. "Pd(OAc)2-catalyzed one-pot preparation of anthranilates from acyclic unsaturated β-enamino esters". . . Retrieved 2020/02/22.
• 2、 Tran, Nga T.T.,Tran, Quan H.,Truong, Thanh. "Removable bidentate directing group assisted-recyclable metal-organic frameworks-catalyzed direct oxidative amination of Sp2 C-H bonds". . p. 9 - 15. Retrieved 2015/09/28.