4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride

Base Information

• Chemical Name: 4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride
• CAS No.: 152402-97-6
• Molecular Formula: C₇H₇Cl₂N*ClH
• Molecular Weight: 212.506
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID10467721
• Mol file: 152402-97-6.mol

Synonyms:Pyridine,4-chloro-2-(chloromethyl)-3-methyl-, hydrochloride (9CI); 4-Chloro-2-chloromethyl-3-methylpyridinehydrochloride

Chemical Property of 4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride

Chemical Property:

• Vapor Pressure: 0.0536mmHg at 25°C
• Boiling Point: 242.2°C at 760 mmHg
• Flash Point: 123.6°C
• PSA: 12.89000
• LogP: 3.58420
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 210.972232
• Heavy Atom Count: 11
• Complexity: 108

Purity/Quality:

99%, ^*data from raw suppliers

2-Chloromethyl-4-(chloro)-3-methylpyridine hydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CN=C1CCl)Cl.Cl

Technology Process of 4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride

There total 4 articles about 4-Chloro-2-(chloromethyl)-3-Methyl Pyridine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-hydroxymethyl-4-chloro-3-methylpyridine (59886-85-0) → 2-chloromethyl-4-chloro-3-methylpyridine hydrochloride (152402-97-6)

Guidance literature:

With thionyl chloride; In dichloromethane; at 25 ℃; for 2h;

Reference yield:

4-chloro-2,3-dimethylpyridine-N-oxide (59886-90-7) → 2-chloromethyl-4-chloro-3-methylpyridine hydrochloride (152402-97-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 5 h / 120 °C

2: NaOH / H₂O / 1 h / 25 °C

3: 80 percent / SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; In dichloromethane; water;

Reference yield:

(4-chloro-3-methylpyridin-2-yl)methyl acetate (59886-84-9) → 2-chloromethyl-4-chloro-3-methylpyridine hydrochloride (152402-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / H₂O / 1 h / 25 °C

2: 80 percent / SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; In dichloromethane; water;

upstream raw materials:

2-hydroxymethyl-4-chloro-3-methylpyridine

(4-chloro-3-methylpyridin-2-yl)methyl acetate

2,3-dimethyl-4-nitropyridine N-oxide

4-chloro-2,3-dimethylpyridine-N-oxide

Downstream raw materials:

2-[(RS)-[(4-chloro-3-methylpyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole

LY 307640 sulfone

rabeprazole sulfide

2-[(4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl-1-oxide)methylsulfonyl]-1H-benzoimidazole