(4-Chloro-3-methylpyridin-2-yl)methyl acetate

Base Information

• Chemical Name: (4-Chloro-3-methylpyridin-2-yl)methyl acetate
• CAS No.: 59886-84-9
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.637
• Hs Code.: 2933399090
• Mol file: 59886-84-9.mol

Synonyms:(4-Chloro-3-methylpyridin-2-yl)methyl acetate

Chemical Property of (4-Chloro-3-methylpyridin-2-yl)methyl acetate

Chemical Property:

• Boiling Point: 263.5±35.0 °C(Predicted)
• PKA: 2.52±0.10(Predicted)
• PSA: 39.19000
• Density: 1.219±0.06 g/cm3(Predicted)
• LogP: 2.10650
• Storage Temp.: 2-8°C
• Solubility.: Chlorofor, Dichloromethane

Purity/Quality:

99.99%HPLC ^*data from raw suppliers

2-Acetoxymethyl-4-chloro-3-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Acetoxymethyl-4-chloro-3-methylpyridine is an intermediate in the synthesis of 4-Desmethoxypropoxyl-4-chloro Rabeprazole which is a process impurity of Rabeprazole (R070500).

Technology Process of (4-Chloro-3-methylpyridin-2-yl)methyl acetate

There total 1 articles about (4-Chloro-3-methylpyridin-2-yl)methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-chloro-2,3-dimethylpyridine-N-oxide (59886-90-7) + acetic anhydride (108-24-7) → (4-chloro-3-methylpyridin-2-yl)methyl acetate (59886-84-9)

Guidance literature:

at 100 ℃; for 3h;

DOI:10.1002/jhet.5570430606

Reference yield:

(4-chloro-3-methylpyridin-2-yl)methyl acetate (59886-84-9) → 2-[(4-chloro-3-methylpyridin-2-yl)methylsulfanyl]-1H-benzoimidazole (103312-62-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / H₂O / 1 h / 25 °C

2: 80 percent / SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

3: 94 percent / NaOH / H₂O / 4 h / 25 °C

With sodium hydroxide; thionyl chloride; In dichloromethane; water;

Reference yield:

(4-chloro-3-methylpyridin-2-yl)methyl acetate (59886-84-9) → 2-chloromethyl-4-chloro-3-methylpyridine hydrochloride (152402-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / H₂O / 1 h / 25 °C

2: 80 percent / SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; In dichloromethane; water;

upstream raw materials:

4-chloro-2,3-dimethylpyridine-N-oxide

acetic anhydride

Downstream raw materials:

2-hydroxymethyl-4-chloro-3-methylpyridine

2-[(4-chloro-3-methylpyridin-2-yl)methylsulfanyl]-1H-benzoimidazole

2-[(RS)-[(4-chloro-3-methylpyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole

2-chloromethyl-4-chloro-3-methylpyridine hydrochloride

Refernces

• 1、 Radl, Stanislav,Klecan, Ondrej,Havlicek, Jaroslav. "Synthetic studies connected with the preparation of H+/K +-ATPase inhibitors rabeprazole and lansoprazole". . p. 1447 - 1453. Retrieved 2007/10/03.