3-Methoxy-2-methylbenzaldehyde

Base Information

• Chemical Name: 3-Methoxy-2-methylbenzaldehyde
• CAS No.: 56724-03-9
• Molecular Formula: C9H10O2
• Molecular Weight: 150.177
• Hs Code.: 2912490090
• European Community (EC) Number: 868-753-5
• DSSTox Substance ID: DTXSID00523729
• Nikkaji Number: J759.685E
• Wikidata: Q82390032
• Mol file: 56724-03-9.mol

Synonyms:3-methoxy-2-methylbenzaldehyde;56724-03-9;3-METHOXY-2-METHYL-BENZALDEHYDE;3-methoxy-2-methylbenzladehyde;MFCD11044581;3-Methoxy 2-methyl benzaldehyde;3-Methoxy-2-methylbenzadehyde;SCHEMBL738533;DTXSID00523729;VUVSSLDCCMJFTM-UHFFFAOYSA-N;2-methyl-3-(methyloxy)benzaldehyde;CL9336;AKOS006306832;3-(PYRROLIDIN-3-YL) PYRIDINE;AS-46299;SY025987;CS-0153510;EN300-214353;A869861;A1-00669;J-512744;Z1198307350

Chemical Property of 3-Methoxy-2-methylbenzaldehyde

Chemical Property:

• Boiling Point: 244.6±20.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.062±0.06 g/cm3(Predicted)
• LogP: 1.81610
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 150.068079557
• Heavy Atom Count: 11
• Complexity: 134

Purity/Quality:

97% ^*data from raw suppliers

3-Methoxy-2-methylbenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC=C1OC)C=O
• Uses: 3-Methoxy-2-methylbenzaldehyde is used as a reagent in the synthesis of benzosuberebe-based inhibitors of tubulin polymerization.

Technology Process of 3-Methoxy-2-methylbenzaldehyde

There total 17 articles about 3-Methoxy-2-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-methoxy-benzaldehyde (591-31-1) + methyl iodide (74-88-4) → 3-methoxy-2-methyl-benzaldehyde (56724-03-9)

Guidance literature:

3-methoxy-benzaldehyde; With n-butyllithium; N,N',N'-trimethylenediamine; In benzene; at 0 - 20 ℃; for 0.25h; Inert atmosphere;

With phenyllithium; In benzene; at 20 ℃; for 12h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; benzene; at -78 - 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2015.10.012

Reference yield: 97.0%

(3-methoxy-2-methylphenyl)methanol (33797-34-1) → 3-methoxy-2-methyl-benzaldehyde (56724-03-9)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 3.5h;

Reference yield: 95.0%

2-(3'-methoxy-o-tolyl)-4,4-dimethyl-N-methyl-2-oxazolinium iodide (72623-18-8) → 3-methoxy-2-methyl-benzaldehyde (56724-03-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 2h; Ambient temperature;

DOI:10.1021/jo01294a035

upstream raw materials:

2-(3'-methoxy-o-tolyl)-4,4-dimethyl-N-methyl-2-oxazolinium iodide

3-methoxy-benzaldehyde

methyl iodide

(E)-N-(3-methoxybenzylidene)cyclohexanamine

Downstream raw materials:

(3-methoxy-2-methylphenyl)methanol

3-bromo-3'-methoxy-2',4-dimethyl-5-nitrostilbene

cis-3-bromo-3'-methoxy-2',4-dimethyl-5-nitrostilbene

trans-3-bromo-3'-methoxy-2',4-dimethyl-5-nitrostilbene