((E)-4-CHLORO-2-METHYL-BUT-2-ENE-1-SULFONYL)-BENZENE(COENZYME Q10 INTERMEDIATE)

Base Information

• Chemical Name: ((E)-4-CHLORO-2-METHYL-BUT-2-ENE-1-SULFONYL)-BENZENE(COENZYME Q10 INTERMEDIATE)
• CAS No.: 5829-79-8
• Molecular Formula: C11H13ClO2S
• Molecular Weight: 244.742
• Mol file: 5829-79-8.mol

Synonyms:((E)-4-CHLORO-2-METHYL-BUT-2-ENE-1-SULFONYL)-BENZENE(COENZYME Q10 INTERMEDIATE)

Chemical Property of ((E)-4-CHLORO-2-METHYL-BUT-2-ENE-1-SULFONYL)-BENZENE(COENZYME Q10 INTERMEDIATE)

Chemical Property:

• PSA: 42.52000
• LogP: 3.72620

Purity/Quality:

99%, ^*data from raw suppliers

[(2E)-4-Chloro-2-methylbut-2-ene-1-sulfonyl]benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: [(2E)-4-Chloro-2-methylbut-2-ene-1-sulfonyl]benzene is derived from Benzenesulfonyl Chloride (B190000), which is used in the synthesis of cecloprotoberberine derivatives as anti-tumor agents.

Technology Process of ((E)-4-CHLORO-2-METHYL-BUT-2-ENE-1-SULFONYL)-BENZENE(COENZYME Q10 INTERMEDIATE)

There total 5 articles about ((E)-4-CHLORO-2-METHYL-BUT-2-ENE-1-SULFONYL)-BENZENE(COENZYME Q10 INTERMEDIATE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzenesulfonyl chloride (98-09-9) + isoprene (78-79-5,9003-31-0) → (E)-4-chloro-2-methyl-1-phenylsulfonyl-2-butene (5829-79-8)

Guidance literature:

With triethylamine hydrochloride; copper(l) chloride; In acetonitrile; at 60 ℃; for 15h;

DOI:10.1021/jo0350155

Reference yield: 65.0%

3,3-dimethyl-1-phenyl-triazene (7227-91-0) + isoprene (78-79-5,9003-31-0) → (E)-4-chloro-2-methyl-1-phenylsulfonyl-2-butene (5829-79-8)

Guidance literature:

With acetic acid; copper(l) chloride; sodium chloride; sulfur dioxide; In water; acetone; at 10 - 15 ℃;

DOI:10.1007/s11176-005-0016-5

Reference yield: 35.0%

1,3-Diphenyltriazen (297766-64-4) + isoprene (78-79-5,9003-31-0) → (E)-4-chloro-2-methyl-1-phenylsulfonyl-2-butene (5829-79-8)

Guidance literature:

With acetic acid; copper(l) chloride; sodium chloride; sulfur dioxide; In water; acetone; at 5 - 10 ℃;

DOI:10.1007/s11176-005-0016-5

upstream raw materials:

benzenesulfonyl chloride

isoprene

buta-1,3-diene

aniline

Downstream raw materials:

2-methyl-1-(phenylsulfonyl)-1,3-butadiene

(E)-4-hydroxy-2-methyl-1-phenylsulfonyl-2-butene

(2'E)-1-(3'-methyl-4'-phenylsulfonylbut-2'-enyl)-6-methyl-2,3,4,5-tetramethoxybenzene

(2′E)-2-(3′-methyl-4′-phenylsulfonylbut-2′-enyl)-1,4-dimethoxy-3-methylnaphthalene

Refernces

• 1、 Min, Jae-Hong,Lee, Jun-Sup,Yang, Jae-Deuk,Koo, Sangho. "The Friedel-Crafts allylation of a prenyl group stabilized by a sulfone moiety: Expeditious syntheses of ubiquinones and menaquinones". . p. 7925 - 7927. Retrieved 2007/10/03.