54089-04-2

Basic information

• Product Name: 2-Pyridinecarboxamide,4-methyl-(9CI)
• Synonyms: 2-Pyridinecarboxamide,4-methyl-(9CI);2-Carbamoyl-3-methylpyridine;4-Methyl-2-PyridinecarboxaMide;4-MethylpicolinaMide;2-Pyridinecarboxamide,4-methyl-
• CAS NO: 54089-04-2
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.153
• Product Categories: AMIDE;Pyridines
• Mol File: 54089-04-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyridinecarboxamide,4-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxamide,4-methyl-(9CI)(54089-04-2)
• EPA Substance Registry System: 2-Pyridinecarboxamide,4-methyl-(9CI)(54089-04-2)

Safety Data

• Hazardous Substances Data: 54089-04-2(Hazardous Substances Data)

Upstream product

• 1620-76-4 2-Cyano-4-methylpyridin 
• 67-56-1 methanol 
• 98-92-0 nicotinamide 
• 108-89-4 picoline 
• 77287-34-4 formamide 
• 4926-28-7 2-Bromo-4-picoline 
• 15226-74-1 dicobalt octacarbonyl 
• 108-75-8 2,4,6-trimethyl-pyridine 
• 1452-77-3 pyridine-2-carboxylic acid amide 

Downstream Products

• 110878-85-8 C₂₄H₂₇N₅⁽²⁺⁾*2I^(1-) 

Relevant articles and documents

Radiation-induced Alkylation, Hydroxyalkylation, and Reduction of Pyridinecarboxamides in Acidic Alcoholic Solutions

The γ-irradiation of pyridinecarboxamides in acidic methanol or ethanol brings about substitution of the ring hydrogen by alkyl or hydroxyalkyl groups derived from the solvent alcohols in relatively high G-values.In 2-propanol, little alkylation and hydroxyalkylation occur and reduction of CONH2 to CH2OH occurs in low G-values.

Acid-Free Silver-Catalyzed Cross-Dehydrogenative Carbamoylation of Pyridines with Formamides

Primary pyridylcarboxamides are prevalent parent structures in bioactive molecules and have the apparent advantages over N-protected derivatives as synthetic building blocks. However, no practical methods have been developed for direct synthesis of this compound class from unfunctionalized pyridines. We herein present a general, safe, concise, acid-free, and highly selective method for the C2-carbamoylation of pyridines with unprotected formamide and N-methyl formamide through the cleavage of two C-H bonds.

Synthesis of primary amides by aminocarbonylation of aryl/hetero halides using non-gaseous NH3 and CO sources

Abstract A practically simple method for the synthesis of primary amides via the palladium-catalysed aminocarbonylation of aromatic halides by using solid sources of gaseous ammonia and carbon monoxide is described. The system tolerated a wide variety of hindered and functionalized aryl/hetero halides and afforded good to excellent yields (69-94%) of the amide. Pharmacologically active Exalamide and Pyrazinecarboxamide were synthesised in high yields to demonstrate the effectiveness of this method.