2H-Furo[2,3-d]imidazol-2-one,5-(aminomethyl)hexahydro-6a-methoxy-,(3aS,5S,6aS)-(9CI)

Base Information

Chemical Name:2H-Furo[2,3-d]imidazol-2-one,5-(aminomethyl)hexahydro-6a-methoxy-,(3aS,5S,6aS)-(9CI)
CAS No.:511272-16-5
Molecular Formula:C7H13N3O3
Molecular Weight:187.2
Hs Code.:
Mol file:511272-16-5.mol

Synonyms:2H-Furo[2,3-d]imidazol-2-one,5-(aminomethyl)hexahydro-6a-methoxy-,(3aS,5S,6aS)-(9CI)

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Chemical Property of 2H-Furo[2,3-d]imidazol-2-one,5-(aminomethyl)hexahydro-6a-methoxy-,(3aS,5S,6aS)-(9CI)

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Technology Process of 2H-Furo[2,3-d]imidazol-2-one,5-(aminomethyl)hexahydro-6a-methoxy-,(3aS,5S,6aS)-(9CI)

There total 8 articles about 2H-Furo[2,3-d]imidazol-2-one,5-(aminomethyl)hexahydro-6a-methoxy-,(3aS,5S,6aS)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 57-13-6
urea

: 475134-54-4
5-azidomethyl-2-(tert-butyl-dimethyl-silanyloxy)-dihydro-furan-3-one

: 475134-56-6,511272-16-5
5-aminomethyl-6a-methoxy-hexahydro-furo[2,3-d]imidazol-2-one

Guidance literature:: methanol; urea; 5-azidomethyl-2-(tert-butyl-dimethyl-silanyloxy)-dihydro-furan-3-one; With hydrogen fluoride; at 20 ℃;

With hydrogen; 10percent Pd/C; In methanol; for 2h; under 760.051 Torr; Further stages.;
DOI:10.1021/ol020112q

Reference yield:

: 14260-66-3
((3αR,5S,6αR)-2,2-dimethyl-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol

: 475134-56-6,511272-16-5
5-aminomethyl-6a-methoxy-hexahydro-furo[2,3-d]imidazol-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 92 percent / Et₃N / CH₂Cl₂ / 20 °C

2.1: 85 percent / NaN₃ / dimethylformamide / 12 h / 85 °C

3.1: Acid hydrolysis

4.1: imidazole; Et₃N / CH₂Cl₂ / 0.75 h

5.1: 72 percent / (COCl)2; DMSO; Et₃N / 2 h

6.1: aq. HF / 20 °C

6.2: H₂ / 10percent Pd/C / methanol / 2 h / 760.05 Torr

With 1H-imidazole; sodium azide; oxalyl dichloride; hydrogen fluoride; dimethyl sulfoxide; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 5.1: Swern oxidation;
DOI:10.1021/ol020112q

Reference yield:

: 41107-52-2
3-deoxy-1,2-O-isopropylidene-5-O-p-tolylsulfonyl-β-L-threo-pentofuranose

: 475134-56-6,511272-16-5
5-aminomethyl-6a-methoxy-hexahydro-furo[2,3-d]imidazol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent / NaN₃ / dimethylformamide / 12 h / 85 °C

2.1: Acid hydrolysis

3.1: imidazole; Et₃N / CH₂Cl₂ / 0.75 h

4.1: 72 percent / (COCl)2; DMSO; Et₃N / 2 h

5.1: aq. HF / 20 °C

5.2: H₂ / 10percent Pd/C / methanol / 2 h / 760.05 Torr

With 1H-imidazole; sodium azide; oxalyl dichloride; hydrogen fluoride; dimethyl sulfoxide; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 4.1: Swern oxidation;
DOI:10.1021/ol020112q