KETAMINE RELATED COMPOUND A (50 MG) (1 -[(2-CHLOROPHENYL)(METHYLIMINO)METHYL]CYLCOPENTA-NOL)

Base Information

• Chemical Name: KETAMINE RELATED COMPOUND A (50 MG) (1 -[(2-CHLOROPHENYL)(METHYLIMINO)METHYL]CYLCOPENTA-NOL)
• CAS No.: 6740-87-0
• Molecular Formula: C13H16ClNO
• Molecular Weight: 237.729
• Hs Code.: 2925294500
• Mol file: 6740-87-0.mol

Synonyms:KETAMINE RELATED COMPOUND A (50 MG) (1 -[(2-CHLOROPHENYL)(METHYLIMINO)METHYL]CYLCOPENTA-NOL);1-((2-Chlorophenyl)(methylimino)methyl)cyclopentanol;1-((2-CHLOROPHENYL)(METHYLIMINO)METHYL)CUCLOPENTANOL

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Chemical Property of KETAMINE RELATED COMPOUND A (50 MG) (1 -[(2-CHLOROPHENYL)(METHYLIMINO)METHYL]CYLCOPENTA-NOL)

Chemical Property:

• Vapor Pressure: 0.03-0.061Pa at 20-25℃
• Melting Point: 64-65 °C
• Boiling Point: 347.3±42.0 °C(Predicted)
• PKA: 13?+-.0.20(Predicted)
• PSA: 32.59000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 3.06400
• Storage Temp.: 2-8°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of KETAMINE RELATED COMPOUND A (50 MG) (1 -[(2-CHLOROPHENYL)(METHYLIMINO)METHYL]CYLCOPENTA-NOL)

There total 14 articles about KETAMINE RELATED COMPOUND A (50 MG) (1 -[(2-CHLOROPHENYL)(METHYLIMINO)METHYL]CYLCOPENTA-NOL) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.8%

(1-Bromocyclopentyl)(2-chlorophenyl)methanone (6740-86-9) + methylamine (74-89-5) → 1-((2-chlorophenyl)(methylimino)methyl)cyclopentan-1-ol (6740-87-0)

Guidance literature:

With water; at 15 - 20 ℃; for 48h; Mechanism;

DOI:10.1021/acs.oprd.9b00553

Reference yield:

(±)-(2-chlorophenyl)(1-hydroxycyclopentyl)methanone (90717-17-2) + methylamine (74-89-5) → 1-((2-chlorophenyl)(methylimino)methyl)cyclopentan-1-ol (6740-87-0) + ketamine (6740-88-1,100477-72-3,33643-46-8,33643-49-1)

Guidance literature:

(±)-(2-chlorophenyl)(1-hydroxycyclopentyl)methanone; methylamine; In ethanol; at 130 ℃; for 0.25h; Flow reactor;

In ethanol; at 180 ℃; for 0.25h; under 25858.1 Torr; Flow reactor;

Reference yield:

(±)-(2-chlorophenyl)(1-hydroxycyclopentyl)methanone (90717-17-2) + methylamine (74-89-5) → 1-((2-chlorophenyl)(methylimino)methyl)cyclopentan-1-ol (6740-87-0) + ketamine (6740-88-1,100477-72-3,33643-46-8,33643-49-1) + N-(2-chlorophenylmethylene)methanamine (17972-08-6)

Guidance literature:

With Triisopropyl borate; In ethanol; at 180 ℃; for 0.166667h; under 12751.3 Torr; Flow reactor;

DOI:10.1039/c9gc00336c

upstream raw materials:

(2-chlorophenyl)(cyclopentyl)methanone

(±)-(2-chlorophenyl)(1-hydroxycyclopentyl)methanone

methylamine

(1-Bromocyclopentyl)(2-chlorophenyl)methanone

Downstream raw materials:

ketamine

N-(2-chlorophenylmethylene)methanamine

(+/-)-ketamine hydrochloride

(S)-ketamine

Refernces

• 1、 Gao, Shenghua,Gao, Xuezhi,Li, Houyong,Yang, Anjiang,Yang, Zhezhou,Zhang, Fuli. "Lewis Acid-Catalyzed Racemization and Recycling of the Undesired (R)-Ketamine". . p. 301 - 305. Retrieved 2020/02/04.
• 2、 -. "IMPROVEMENTS IN OR RELATING TO ORGANIC MATERIAL". . . Retrieved 2019/07/17.