Methanamine, N-[(2-chlorophenyl)methylene]-

Base Information

• Chemical Name: Methanamine, N-[(2-chlorophenyl)methylene]-
• CAS No.: 17972-08-6
• Molecular Formula: C8H8ClN
• Molecular Weight: 153.611
• Mol file: 17972-08-6.mol

Synonyms:2-Chlor-N-methyl-benzaldimin;N-Methyl-O-chlorobenzylidenimine;Methylamine, N-(o-chlorobenzylidene)-;

Chemical Property of Methanamine, N-[(2-chlorophenyl)methylene]-

Chemical Property:

• Melting Point: 7°C
• Refractive Index: 1.5660 (estimate)
• Boiling Point: 252.49°C (rough estimate)
• PSA: 12.36000
• Density: 1.1558 (rough estimate)
• LogP: 2.38870

Purity/Quality:

97% purity ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanamine, N-[(2-chlorophenyl)methylene]-

There total 9 articles about Methanamine, N-[(2-chlorophenyl)methylene]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-chloro-benzaldehyde (89-98-5) + methylamine (74-89-5) → N-(2-chlorophenylmethylene)methanamine (17972-08-6)

Guidance literature:

In methanol; dichloromethane; for 18h; Molecular sieve;

DOI:10.1021/ol503024d

Reference yield: 88.0%

methylamine hydrochloride (593-51-1) + 2-chloro-benzaldehyde (89-98-5) → N-(2-chlorophenylmethylene)methanamine (17972-08-6)

Guidance literature:

With 1,1'-(1,4-butanediyl)bis(imidazole); In neat (no solvent); at 20 ℃; for 10h; Milling;

DOI:10.1071/CH18408

Reference yield:

(±)-(2-chlorophenyl)(1-hydroxycyclopentyl)methanone (90717-17-2) + methylamine (74-89-5) → 1-((2-chlorophenyl)(methylimino)methyl)cyclopentan-1-ol (6740-87-0) + ketamine (6740-88-1,100477-72-3,33643-46-8,33643-49-1) + N-(2-chlorophenylmethylene)methanamine (17972-08-6)

Guidance literature:

With Triisopropyl borate; In ethanol; at 180 ℃; for 0.166667h; under 12751.3 Torr; Flow reactor;

DOI:10.1039/c9gc00336c

upstream raw materials:

2-chloro-benzaldehyde

methylamine

methylamine hydrochloride

N-methyl-N-(2-chlorobenzyl)amine

Downstream raw materials:

(R)-N-(cyano(4-fluorophenyl)methyl)-N-methylacetamide

(R)-N-((2-chlorophenyl)(cyano)methyl)-N-methylacetamide

(R)-N-(cyano(2,4-difluorophenyl)methyl)-N-methylacetamide

(2-Chloro-phenyl)-methylamino-acetonitrile