6-Ethoxy-2-pyridinamine

Base Information

• Chemical Name: 6-Ethoxy-2-pyridinamine
• CAS No.: 768-42-3
• Molecular Formula: C7H10N2O
• Molecular Weight: 138.169
• Hs Code.: 29339900
• European Community (EC) Number: 872-137-1
• DSSTox Substance ID: DTXSID70343017
• Wikidata: Q72472040
• Mol file: 768-42-3.mol

Synonyms:6-Ethoxy-2-pyridinamine;6-ethoxypyridin-2-amine;768-42-3;6-ETHOXY-PYRIDIN-2-YLAMINE;2-Amino-6-ethoxypyridine;6-amino-2-ethoxypyridine;6-ethoxypyridin-2-ylamine;6-amino-2-ethoxy pyridine;6-Ethoxy-2-pyridinamine #;Pyridin-2-amine, 6-ethoxy-;SCHEMBL107591;DTXSID70343017;MFCD00235129;AKOS012899704;AB05302;AC-13283;A9735;CS-0061653;FT-0687911;EN300-89876;J-518686;Z1139188017;(R)-3,3-Bis(2,4,6-triisopropylphenyl)-1,1-binaphthyl-2,2-diyl hydrogenphosphate

Chemical Property of 6-Ethoxy-2-pyridinamine

Chemical Property:

• Vapor Pressure: 0.03mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 244.7 °C at 760 mmHg
• Flash Point: 101.8 °C
• PSA: 48.14000
• Density: 1.101 g/cm³
• LogP: 1.64370
• Storage Temp.: 2-8°C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 138.079312947
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

97% ^*data from raw suppliers

6-ethoxypyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 24/25-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC(=N1)N

Technology Process of 6-Ethoxy-2-pyridinamine

There total 4 articles about 6-Ethoxy-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

6-chloropyridin-2-amine (45644-21-1) + methanol (67-56-1) → 6-ethoxypyridin-2-amine (768-42-3)

Guidance literature:

With sodium ethanolate; In ethanol; at 25 - 140 ℃; for 81h; Sealed tube;

Reference yield:

2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) → 6-ethoxypyridin-2-amine (768-42-3)

Guidance literature:

With ethanol; sodium ethanolate; at 160 ℃;

Reference yield:

2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) + ethanol (64-17-5) → 6-ethoxypyridin-2-amine (768-42-3)

Guidance literature:

With potassium tert-butylate; at 130 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.bmcl.2014.12.028

upstream raw materials:

2-Amino-6-bromopyridine

6-chloropyridin-2-amine

methanol

ethanol

Downstream raw materials:

6-((1R,2S)-2-aminocyclohexylamino)-4-(6-ethoxypyridin-2-ylamino)pyridazine-3-carboxamide

tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-ethoxypyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate