3-Fluoro-2-(bromomethyl)benzonitrile

Base Information

• Chemical Name: 3-Fluoro-2-(bromomethyl)benzonitrile
• CAS No.: 635723-84-1
• Molecular Formula: C8H5 Br F N
• Molecular Weight: 214.037
• Hs Code.: 2926909090
• Mol file: 635723-84-1.mol

Synonyms:2-Bromomethyl-3-fluorobenzonitrile;2-Cyano-6-fluorobenzyl bromide

Chemical Property of 3-Fluoro-2-(bromomethyl)benzonitrile

Chemical Property:

• Boiling Point: 258℃
• Flash Point: 110℃
• PSA: 23.79000
• Density: 1.59
• LogP: 2.59228
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Bromomethyl)-3-fluorobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoro-2-(bromomethyl)benzonitrile

There total 1 articles about 3-Fluoro-2-(bromomethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3-fluoro-2-methylbenzonitrile (185147-06-2) → 2-(bromomethyl)-3-fluorobenzonitrile (635723-84-1)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; Reflux;

Reference yield: 99.0%

pyrrolidine (123-75-1) + 2-(bromomethyl)-3-fluorobenzonitrile (635723-84-1) → 3-fluoro-2-(pyrrolidin-1-ylmethyl)benzonitrile

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 16h;

Reference yield: 96.0%

2-(bromomethyl)-3-fluorobenzonitrile (635723-84-1) + 2,2-dimethylazetidine (1086266-55-8) → 2-((2,2-dimethylazetidin-1-yl)methyl)-3-fluorobenzonitrile

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

upstream raw materials:

3-fluoro-2-methylbenzonitrile

Downstream raw materials:

C₁₆H₉FN₂O₂

C₁₇H₂₀BrFN₂O₂

Refernces

• 1、 -. "NRF2 REGULATORS". Page/Page column 161. . Retrieved 2017/01/02.
• 2、 -. "Imidazole derivatives as PDE10A enzyme inhibitors". Page/Page column 12. . Retrieved 2012/06/01.