1-(Trimethylsilyldifluoromethyl)-2-methyl-1H-benzoimidazole

Base Information

Chemical Name:1-(Trimethylsilyldifluoromethyl)-2-methyl-1H-benzoimidazole
CAS No.:341529-09-7
Molecular Formula:C12H16 F2 N2 Si
Molecular Weight:254.35100
Hs Code.:2933990090
DSSTox Substance ID:DTXSID90375375
Wikidata:Q82163906
Mol file:341529-09-7.mol

Synonyms:341529-09-7;1-(Trimethylsilyldifluoromethyl)-2-methyl-1H-benzoimidazole;[difluoro-(2-methylbenzimidazol-1-yl)methyl]-trimethylsilane;1-(Difluoro(trimethylsilyl)methyl)-2-methyl-1H-benzo[d]imidazole;1-(trimethylsilildifluoromethyl)-2-methyl-benzimidazole;DTXSID90375375;ZOOUJHPYEIPJMA-UHFFFAOYSA-N;1-[difluoro(trimethylsilyl)methyl]-2-methyl-1H-1,3-benzodiazole;1H-BENZIMIDAZOLE,1-[DIFLUORO(TRIMETHYLSILYL)METHYL]-2-METHYL-

Suppliers and Price of 1-(Trimethylsilyldifluoromethyl)-2-methyl-1H-benzoimidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
1-(Difluoro(trimethylsilyl)methyl)-2-methyl-1H-benzo[d]imidazole 95%
1g
$ 346.00

Total 7 raw suppliers

Chemical Property of 1-(Trimethylsilyldifluoromethyl)-2-methyl-1H-benzoimidazole

Chemical Property:

Vapor Pressure:0.00135mmHg at 25°C
Boiling Point:307oC at 760 mmHg
Flash Point:139.5oC
PSA：17.82000
Density:1.1g/cm3
LogP:4.08290
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:254.10508138
Heavy Atom Count:17
Complexity:291

Purity/Quality:

98% ^*data from raw suppliers

1-(Difluoro(trimethylsilyl)methyl)-2-methyl-1H-benzo[d]imidazole 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC2=CC=CC=C2N1C(F)(F)[Si](C)(C)C

Technology Process of 1-(Trimethylsilyldifluoromethyl)-2-methyl-1H-benzoimidazole

There total 2 articles about 1-(Trimethylsilyldifluoromethyl)-2-methyl-1H-benzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 75-77-4
chloro-trimethyl-silane

: 273405-42-8
1-Bromodifluoromethyl-2-methylbenzimidazole

: 341529-09-7
2-Methylbenzimidazole-1-yldifluoromethyltrimethylsilane

Guidance literature:: With P(NEt)3; In dichloromethane; at -70 ℃; for 1h;
DOI:10.1055/s-2001-11389

Reference yield:

: 615-15-6
2-Methyl-1H-benzimidazole

: 341529-09-7
2-Methylbenzimidazole-1-yldifluoromethyltrimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: tBuOK / tetrahydrofuran

1.2: dimethylformamide / 20 °C

2.1: 82 percent / P(NEt)3 / CH₂Cl₂ / 1 h / -70 °C

With P(NEt)3; potassium tert-butylate; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2001-11389

Reference yield: 81.0%

: 100-52-7
benzaldehyde

: 341529-09-7
2-Methylbenzimidazole-1-yldifluoromethyltrimethylsilane

: 273405-47-3
2-Methylbenzimidazol-1-yl-2,2-difluoro-1-phenylethanol

Guidance literature:: benzaldehyde; 2-Methylbenzimidazole-1-yldifluoromethyltrimethylsilane; With tetramethylammonium fluoride; In 1,2-dimethoxyethane; for 20h;

With hydrogenchloride;
DOI:10.1016/S0022-1139(01)00390-6