PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-METHYL ESTER

Base Information

• Chemical Name: PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-METHYL ESTER
• CAS No.: 174543-74-9
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Hs Code.: 2933399090
• Mol file: 174543-74-9.mol

Synonyms:Methyl 1-[benzyloxycarbonyl]piperidine-3-carboxylate;Methyl N- Cbz -piperidine-3-carboxylate;Piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester;

Chemical Property of PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-METHYL ESTER

Chemical Property:

• Refractive Index: 1.538
• Boiling Point: 390.418 °C at 760 mmHg
• PKA: -2.53±0.40(Predicted)
• Flash Point: 189.918 °C
• PSA: 55.84000
• Density: 1.188 g/cm³
• LogP: 2.14610
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl3-MethylPiperidine-1,3-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-METHYL ESTER

There total 3 articles about PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methanol (67-56-1) + 1-benzyloxycarbonylpiperidine-3-carboxylic acid (78190-11-1) → N-benzyloxycarbonyl nipecotic acid methyl ester (174543-74-9)

Guidance literature:

With tert.-butylnitrite; at 40 ℃; for 48h;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonyl nipecotic acid methyl ester (174543-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / NaHCO₃ / dioxane

2: HCl

With hydrogenchloride; sodium hydrogencarbonate; In 1,4-dioxane;

DOI:10.1016/0040-4039(95)02378-X

Reference yield:

nipecotic acid (498-95-3,262853-93-0) → N-benzyloxycarbonyl nipecotic acid methyl ester (174543-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / NaHCO₃ / dioxane

2: HCl

With hydrogenchloride; sodium hydrogencarbonate; In 1,4-dioxane;

DOI:10.1016/0040-4039(95)02378-X

upstream raw materials:

methanol

1-benzyloxycarbonylpiperidine-3-carboxylic acid

benzyl chloroformate

nipecotic acid

Downstream raw materials:

3-Methyl-piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester

3-Amino-3-methyl-piperidine-1-carboxylic acid benzyl ester

3-Carbamoyl-3-methyl-piperidine-1-carboxylic acid benzyl ester

1-((benzyloxy)carbonyl)-3-methylpiperidine-3-carboxylic acid