C₃₀H₃₉N₅O₁₇P₂

Base Information

• Chemical Name: C₃₀H₃₉N₅O₁₇P₂
• CAS No.: 160343-28-2
• Molecular Formula: C₃₀H₃₉N₅O₁₇P₂
• Molecular Weight: 803.61
• Mol file: 160343-28-2.mol

Synonyms:

Chemical Property of C₃₀H₃₉N₅O₁₇P₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₃₉N₅O₁₇P₂

There total 6 articles about C₃₀H₃₉N₅O₁₇P₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C51H57N5O19P2 (160343-20-4) → C30H39N5O17P2 (160343-28-2)

Guidance literature:

With acetic acid; for 3h; Ambient temperature;

DOI:10.1080/15257779408011881

Reference yield:

3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate (130856-82-5) → C30H39N5O17P2 (160343-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / t-BuNH₂ / methanol / 1.) -20 deg C, 12 h, 2.) -20 deg C -> room temperature, 5 h

2: 1.) tetrazole, 2.) I₂ / 1.) MeCN, room temperature, overnight, 2.) 2,6-lutidine, THF, H₂O, 2 min

3: 60 percent / aq. AcOH / 3 h / Ambient temperature

With 1H-tetrazole; iodine; acetic acid; tert-butylamine; In methanol;

DOI:10.1080/15257779408011881

Reference yield:

3'-O-acetylthymidine (21090-30-2) → C30H39N5O17P2 (160343-28-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) tetrazole, 2.) I₂ / 1.) MeCN, room temperature, overnight, 2.) 2,6-lutidine, THF, H₂O, 2 min

2: 74 percent / t-BuNH₂ / methanol / 1.) -20 deg C, 12 h, 2.) -20 deg C -> room temperature, 5 h

3: 1.) tetrazole, 2.) I₂ / 1.) MeCN, room temperature, overnight, 2.) 2,6-lutidine, THF, H₂O, 2 min

4: 60 percent / aq. AcOH / 3 h / Ambient temperature

With 1H-tetrazole; iodine; acetic acid; tert-butylamine; In methanol;

DOI:10.1080/15257779408011881

upstream raw materials:

C₅₁H₅₇N₅O₁₉P₂

3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate

3'-O-acetylthymidine

[5'-O-(4,4'-dimethoxytrityl)thymidine-3'-yl]-(N,N'-diisopropyl)methylphosphoramidite