3-Hydroxy-alpha-((4-(3-methyl-1H-indol-2-yl)phenoxy)methyl)-1-piperidineethanol

Base Information

• Chemical Name: 3-Hydroxy-alpha-((4-(3-methyl-1H-indol-2-yl)phenoxy)methyl)-1-piperidineethanol
• CAS No.: 88737-51-3
• Molecular Formula: C₂₃H₂₈N₂O₃
• Molecular Weight: 380.487
• DSSTox Substance ID: DTXSID001008332
• Mol file: 88737-51-3.mol

Synonyms:BRN 4552186;3-Hydroxy-alpha-((4-(3-methyl-1H-indol-2-yl)phenoxy)methyl)-1-piperidineethanol;1-Piperidineethanol, 3-hydroxy-alpha-((4-(3-methyl-1H-indol-2-yl)phenoxy)methyl)-;88737-51-3;DTXSID001008332;LS-115430;1-{2-Hydroxy-3-[4-(3-methyl-1H-indol-2-yl)phenoxy]propyl}piperidin-3-ol

Chemical Property of 3-Hydroxy-alpha-((4-(3-methyl-1H-indol-2-yl)phenoxy)methyl)-1-piperidineethanol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 635.094°C at 760 mmHg
• Flash Point: 337.893°C
• Density: 1.232g/cm³
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 380.20999276
• Heavy Atom Count: 28
• Complexity: 483

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(NC2=CC=CC=C12)C3=CC=C(C=C3)OCC(CN4CCCC(C4)O)O

Technology Process of 3-Hydroxy-alpha-((4-(3-methyl-1H-indol-2-yl)phenoxy)methyl)-1-piperidineethanol

There total 4 articles about 3-Hydroxy-alpha-((4-(3-methyl-1H-indol-2-yl)phenoxy)methyl)-1-piperidineethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

3-hydroxypiperazine (6859-99-0) + 1--2,3-epoxypropane (88737-43-3) → 1--3-(3-hydroxy-1-piperidyl)-propan-2-ol (88737-51-3)

Guidance literature:

In methanol; Heating;

Reference yield:

4-(3-methyl-1H-indol-2-yl)phenol (69181-53-9) → 1--3-(3-hydroxy-1-piperidyl)-propan-2-ol (88737-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / K₂CO₃ / Heating

2: 63 percent / methanol / Heating

With potassium carbonate; In methanol;

Reference yield:

phenylhydrazine (100-63-0) → 1--3-(3-hydroxy-1-piperidyl)-propan-2-ol (88737-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 25 percent / conc. HCl / ethanol; H₂O / 5 h / Heating

2: 73 percent / K₂CO₃ / Heating

3: 63 percent / methanol / Heating

With hydrogenchloride; potassium carbonate; In methanol; ethanol; water;

upstream raw materials:

3-hydroxypiperazine

1--2,3-epoxypropane

4-(3-methyl-1H-indol-2-yl)phenol

phenylhydrazine