1-(4-fluoro-3-nitrobenzyl)piperidine

Base Information

Chemical Name:1-(4-fluoro-3-nitrobenzyl)piperidine
CAS No.:509093-74-7
Molecular Formula:C12H15 F N2 O2
Molecular Weight:238.262
Hs Code.:
Mol file:509093-74-7.mol

Synonyms:1-(4-Fluoro-3-nitrobenzyl)piperidine

Suppliers and Price of 1-(4-fluoro-3-nitrobenzyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-(4-Fluoro-3-nitrobenzyl)piperidine 95+%
1g
$ 377.00

Chemenu
1-(4-fluoro-3-nitrobenzyl)piperidine 95%
1g
$ 356.00

Alichem
1-(4-Fluoro-3-nitrobenzyl)piperidine
1g
$ 400.00

Total 10 raw suppliers

Chemical Property of 1-(4-fluoro-3-nitrobenzyl)piperidine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:346.64oC at 760 mmHg
PKA:7.69±0.10(Predicted)
Flash Point:163.442oC
PSA：49.06000
Density:1.242g/cm3
LogP:3.18090
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Fluoro-3-nitrobenzyl)piperidine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(4-fluoro-3-nitrobenzyl)piperidine

There total 3 articles about 1-(4-fluoro-3-nitrobenzyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 110-89-4
piperidine

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 509093-74-7
1-[(4-fluoro-3-nitrophenyl)methyl]piperidine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2015.10.060

Reference yield:

: 20274-69-5
(4-fluoro-3-nitrophenyl)methanol

: 509093-74-7
1-[(4-fluoro-3-nitrophenyl)methyl]piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hypochlorite; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; dichloromethane

2: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium tris(acetoxy)borohydride; acetic acid; potassium bromide; In dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2015.10.060

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 509093-74-7
1-[(4-fluoro-3-nitrophenyl)methyl]piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran

2: sodium hypochlorite; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; dichloromethane

3: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane

With sodium hypochlorite; borane-THF; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium tris(acetoxy)borohydride; acetic acid; potassium bromide; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2015.10.060