2-Acetamido-4-fluorotoluene

Base Information

• Chemical Name: 2-Acetamido-4-fluorotoluene
• CAS No.: 366-49-4
• Molecular Formula: C9H10FNO
• Molecular Weight: 167.183
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID50393292
• Wikidata: Q72434048
• Mol file: 366-49-4.mol

Synonyms:366-49-4;2-ACETAMIDO-4-FLUOROTOLUENE;N-Acetyl 5-fluoro-2-methylaniline;N-(5-fluoro-2-methylphenyl)acetamide;Acetamide, N-(5-fluoro-2-methylphenyl)-;MFCD00045064;SCHEMBL1887376;DTXSID50393292;OSXGBILCTZUOGO-UHFFFAOYSA-N;AKOS005216496;N-(5-Fluoro-2-methyl-phenyl)-acetamide;AS-48006;SY005884;CS-0135130;FT-0729883;F17525;Z30904143;2-Hydroxy-4-isopropyl-3-quinolinecarboxylicacidmethylester

Chemical Property of 2-Acetamido-4-fluorotoluene

Chemical Property:

• Vapor Pressure: 0.00361mmHg at 25°C
• Boiling Point: 281.2oC at 760 mmHg
• Flash Point: 123.9°C
• PSA: 29.10000
• Density: 1.169g/cm³
• LogP: 2.16550
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 167.074642105
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

N-Acetyl 5-fluoro-2-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=C(C=C1)F)NC(=O)C

Technology Process of 2-Acetamido-4-fluorotoluene

There total 6 articles about 2-Acetamido-4-fluorotoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

→ 5’-fluoro-2’-methylacetanilide (366-49-4)

Guidance literature:

Reference yield: 90.0%

3-fluoro-6-methylaniline (367-29-3) + acetic anhydride (108-24-7) → 5’-fluoro-2’-methylacetanilide (366-49-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield: 86.0%

3-fluoro-6-methylaniline (367-29-3) + acetyl chloride (75-36-5) → 5’-fluoro-2’-methylacetanilide (366-49-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h;

upstream raw materials:

3-fluoro-6-methylaniline

acetic anhydride

2-nitro-4-fluorotoluene

acetyl chloride

Downstream raw materials:

2-acetamido-4-fluorobenzoic acid

4-fluoroanthranilic acid

N-(5-fluoro-2-methyl-4-nitrophenyl)acetamide

N-(4-bromo-5-fluoro-2-methylphenyl)acetamide