2-[2-({1-[2-(2-{[1-(2,2-dimethylpropionyl)pyrrolidine-2-carbonyl]amino}benzoylamino)benzoyl]pyrrolidine-2-carbonyl}amino)benzoylamino]benzoic acid methyl amide

Base Information

Chemical Name:2-[2-({1-[2-(2-{[1-(2,2-dimethylpropionyl)pyrrolidine-2-carbonyl]amino}benzoylamino)benzoyl]pyrrolidine-2-carbonyl}amino)benzoylamino]benzoic acid methyl amide
CAS No.:1448441-05-1
Molecular Formula:C₄₄H₄₇N₇O₇
Molecular Weight:785.9
Hs Code.:

2-[2-({1-[2-(2-{[1-(2,2-dimethylpropionyl)pyrrolidine-2-carbonyl]amino}benzoylamino)benzoyl]pyrrolidine-2-carbonyl}amino)benzoylamino]benzoic acid methyl amide

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Chemical Property of 2-[2-({1-[2-(2-{[1-(2,2-dimethylpropionyl)pyrrolidine-2-carbonyl]amino}benzoylamino)benzoyl]pyrrolidine-2-carbonyl}amino)benzoylamino]benzoic acid methyl amide

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Technology Process of 2-[2-({1-[2-(2-{[1-(2,2-dimethylpropionyl)pyrrolidine-2-carbonyl]amino}benzoylamino)benzoyl]pyrrolidine-2-carbonyl}amino)benzoylamino]benzoic acid methyl amide

There total 15 articles about 2-[2-({1-[2-(2-{[1-(2,2-dimethylpropionyl)pyrrolidine-2-carbonyl]amino}benzoylamino)benzoyl]pyrrolidine-2-carbonyl}amino)benzoylamino]benzoic acid methyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1448441-07-3
2-[2-({1-[2-(2-{[1-(2,2-dimethylpropionyl)pyrrolidine-2-carbonyl]amino}benzoylamino)benzoyl]pyrrolidine-2-carbonyl}amino)benzoylamino]benzoic acid methyl ester

: 74-89-5
methylamine

: 1448441-05-1
2-[2-({1-[2-(2-{[1-(2,2-dimethylpropionyl)pyrrolidine-2-carbonyl]amino}benzoylamino)benzoyl]pyrrolidine-2-carbonyl}amino)benzoylamino]benzoic acid methyl amide

Guidance literature:: In methanol; at 20 ℃; for 1h;
DOI:10.1021/ja405455g

Reference yield:

: 134-20-3
2-carbomethoxyaniline

: 1448441-05-1
2-[2-({1-[2-(2-{[1-(2,2-dimethylpropionyl)pyrrolidine-2-carbonyl]amino}benzoylamino)benzoyl]pyrrolidine-2-carbonyl}amino)benzoylamino]benzoic acid methyl amide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane

2: palladium(II) hydroxide; methanol / 4 h

3: tetrahydrofuran / 0 - 70 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 0 °C / Molecular sieve

6: methanol / 1 h / 20 °C

With methanol; palladium(II) hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja405455g

Reference yield:

: 610-14-0
2-nitrobenzyl chloride

: 1448441-05-1
2-[2-({1-[2-(2-{[1-(2,2-dimethylpropionyl)pyrrolidine-2-carbonyl]amino}benzoylamino)benzoyl]pyrrolidine-2-carbonyl}amino)benzoylamino]benzoic acid methyl amide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane

2: palladium(II) hydroxide; methanol / 4 h

3: tetrahydrofuran / 0 - 70 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 0 °C / Molecular sieve

6: methanol / 1 h / 20 °C

With methanol; palladium(II) hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja405455g