2-Chloro-3-(trichloromethyl)pyridine

Base Information

• Chemical Name: 2-Chloro-3-(trichloromethyl)pyridine
• CAS No.: 72648-12-5
• Molecular Formula: C6H3F4N
• Molecular Weight: 230.909
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID40345740
• Wikidata: Q72460024
• Mol file: 72648-12-5.mol

Synonyms:2-Chloro-3-(trichloromethyl)pyridine;72648-12-5;2-CHLORO-3-TRICHLOROMETHYLPYRIDINE;2-chloro-3-trichloromethyl pyridine;SCHEMBL4764441;DTXSID40345740;2-chloro-3-trichloro-methylpyridine;AMY21955;XCA64812;MFCD00160150;STK842508;AKOS000267766;DS-8881;CS-0060694;EU-0066805;FT-0768367;A856465

Chemical Property of 2-Chloro-3-(trichloromethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.0034mmHg at 25°C
• Refractive Index: 1.575
• Boiling Point: 291.5 °C at 760 mmHg
• Flash Point: 157.7 °C
• PSA: 12.89000
• Density: 1.582 g/cm³
• LogP: 3.56170
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 230.899010
• Heavy Atom Count: 11
• Complexity: 133

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-3-(trichloromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)Cl)C(Cl)(Cl)Cl

Technology Process of 2-Chloro-3-(trichloromethyl)pyridine

There total 7 articles about 2-Chloro-3-(trichloromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

3‐(trichloromethyl)‐1-pyridine-N-oxide → 2-chloro-3-(trichloromethyl)-pyridine (72648-12-5)

Guidance literature:

With triethylamine; trichlorophosphate; In dichloromethane; at 10 - 25 ℃; Reagent/catalyst;

Reference yield: 72.0%

2-hydroxy-3-carboxypyridine (609-71-2) → 2-chloro-3-(trichloromethyl)-pyridine (72648-12-5)

Guidance literature:

With P,P-dichlorophenylphosphine oxide; phosphorus pentachloride; at 160 ℃; for 5h;

DOI:10.1080/00397911.2016.1218897

Reference yield:

3-Methylpyridine (108-99-6) → nicotinyl chloride (3099-31-8) + 2-chloro-5-(Trichloromethyl)-pyridine (69045-78-9) + 2-chloro-3-(trichloromethyl)-pyridine (72648-12-5) + 2,3-dichloro-5-(trichloromethyl)pyridine (69045-83-6)

Guidance literature:

With tetrachloromethane; at 200 - 350 ℃; for 0.00305556h; Molecular sieve; Inert atmosphere;

upstream raw materials:

3-Methylpyridine

2-hydroxy-3-carboxypyridine

Downstream raw materials:

2,6-dimethoxypyridine-3-carboxaldehyde

2-chloro-6-methoxy-3-pyridine-carboxaldehyde

2-chloro-3-(dimethoxymethyl)-6-methoxypyridine

2-chloro-3-dichloromethyl-6-methoxypyridine