3-Bromo-furan-2-carboxylic acid methylamide

Base Information

• Chemical Name: 3-Bromo-furan-2-carboxylic acid methylamide
• CAS No.: 816418-32-3
• Molecular Formula: C6H6BrNO2
• Molecular Weight: 204.02100
• Mol file: 816418-32-3.mol

Synonyms:

Chemical Property of 3-Bromo-furan-2-carboxylic acid methylamide

Chemical Property:

• PSA: 42.24000
• LogP: 1.79260

Purity/Quality:

99% ^*data from raw suppliers

3-BROMO-FURAN-2-CARBOXYLIC ACID METHYLAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-furan-2-carboxylic acid methylamide

There total 2 articles about 3-Bromo-furan-2-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromofuran-2-carboxylic acid (14903-90-3) → 3-bromofuran-2-carboxylic acid methylamide (816418-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1: SO₂Cl₂; DMF / 3 h / Heating

2: CH₂Cl₂ / 0 - 20 °C

With sulfuryl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/ol0479949

Reference yield:

3-bromo-furan-2-carbonyl chloride (58777-57-4) + methylamine (74-89-5) → 3-bromofuran-2-carboxylic acid methylamide (816418-32-3)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol0479949

Reference yield: 82.0%

ortho-methylphenyl iodide (615-37-2) + 3-bromofuran-2-carboxylic acid methylamide (816418-32-3) → 5,6-dimethyl-5H-furo[2,3-c]quinolin-4-one (816418-42-5)

Guidance literature:

With palladium diacetate; trifuran-2-yl-phosphane; potassium carbonate; norborn-2-ene; In N,N-dimethyl-formamide; at 85 ℃; for 24h;

DOI:10.1021/ol0479949

upstream raw materials:

3-bromo-furan-2-carbonyl chloride

methylamine

3-bromofuran-2-carboxylic acid

Downstream raw materials:

5,6-dimethyl-5H-furo[2,3-c]quinolin-4-one

Refernces