7-BROMO-1-METHYL-1H-INDAZOLE

Base Information

• Chemical Name: 7-BROMO-1-METHYL-1H-INDAZOLE
• CAS No.: 1000576-59-9
• Molecular Formula: C₈H₇BrN₂
• Molecular Weight: 211.061
• Hs Code.: 2933990090
• Mol file: 1000576-59-9.mol

Synonyms:7-Bromo-1-methyl-1H-indazole;

Chemical Property of 7-BROMO-1-METHYL-1H-INDAZOLE

Chemical Property:

• Boiling Point: 293.6 °C at 760 mmHg
• Flash Point: 131.4 °C
• PSA: 17.82000
• Density: 1.6 g/cm³
• LogP: 2.33580
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Bromo-1-methyl-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Bromo-1-methyl-indazole acts as a reagent in the synthesis of cyclic benzimidazole derivatives which functions as protein kinase activators that are used in the treatment of type 2 diabetics, hyperglycemia and other related diseases.

Technology Process of 7-BROMO-1-METHYL-1H-INDAZOLE

There total 2 articles about 7-BROMO-1-METHYL-1H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.2%

7-bromo-1H-indazole (53857-58-2) + methyl iodide (74-88-4) → 7-bromo-2-methyl-2H-indazole (701910-14-7) + 7-bromo-1-methyl-1H-indazole (1000576-59-9)

Guidance literature:

7-bromo-1H-indazole; With potassium carbonate; In N,N-dimethyl-formamide; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 25 ℃; for 3h;

Reference yield: 45.0%

7-bromo-2H-indazole (845751-59-9,53857-58-2) + dimethyl sulfate (77-78-1) → 7-bromo-2-methyl-2H-indazole (701910-14-7) + 7-bromo-1-methyl-1H-indazole (1000576-59-9)

Guidance literature:

7-bromo-2H-indazole; With sodium hydroxide; In water; Heating / reflux;

dimethyl sulfate; In water; at 65 ℃; for 2h;

Reference yield: 90.1%

7-bromo-1-methyl-1H-indazole (1000576-59-9) + bis(pinacol)diborane (73183-34-3) → C14H19BN2O2

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In N,N-dimethyl-formamide; at 85 ℃; for 12h;

upstream raw materials:

7-bromo-2H-indazole

dimethyl sulfate

7-bromo-1H-indazole

methyl iodide

Downstream raw materials:

4-((4-(1-methyl-1H-indazol-7-yl)-1,4-diazepan-1-yl)methyl)-2-phenylthiazole

Refernces

• 1、 -. "CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF". Paragraph 0344-0346. . Retrieved 2019/10/23.