N-(4-fluorophenyl)-2-(methylamino)acetamide

Base Information

• Chemical Name: N-(4-fluorophenyl)-2-(methylamino)acetamide
• CAS No.: 900641-75-0
• Molecular Formula: C₉H₁₁FN₂O
• Molecular Weight: 182.198
• DSSTox Substance ID: DTXSID201262641
• ChEMBL ID: CHEMBL4532045
• Mol file: 900641-75-0.mol

Synonyms:N-(4-fluorophenyl)-2-(methylamino)acetamide;900641-75-0;MFCD04639676;SCHEMBL7140174;CHEMBL4532045;DTXSID201262641;STK504218;AKOS000198970;GR-0001;N-(4-fluorophenyl)-N~2~-methylglycinamide;CS-0301437;EN300-34204;Z46191184

Chemical Property of N-(4-fluorophenyl)-2-(methylamino)acetamide

Chemical Property:

• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 182.08554114
• Heavy Atom Count: 13
• Complexity: 167

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-Fluorophenyl)-2-(methylamino)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNCC(=O)NC1=CC=C(C=C1)F

Technology Process of N-(4-fluorophenyl)-2-(methylamino)acetamide

There total 2 articles about N-(4-fluorophenyl)-2-(methylamino)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-N-(4-fluorophenyl)acetamide (351-04-2) + methylamine (74-89-5) → C9H11FN2O (900641-75-0)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 24h;

DOI:10.1111/j.1747-0285.2011.01138.x

Reference yield:

4-fluoroaniline (371-40-4) → C9H11FN2O (900641-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4 h / 0 °C

2: potassium carbonate / methanol / 24 h / 20 °C

With potassium carbonate; triethylamine; In methanol; dichloromethane;

DOI:10.1111/j.1747-0285.2011.01138.x

Reference yield:

C9H11FN2O (900641-75-0) + 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate (86386-77-8) → C20H20F3N5O2 (1239174-73-2)

Guidance literature:

With triethylamine; In ethanol; for 9h; Reflux;

DOI:10.1111/j.1747-0285.2011.01138.x

upstream raw materials:

2-chloro-N-(4-fluorophenyl)acetamide

methylamine

4-fluoroaniline

Downstream raw materials:

C₂₀H₂₀F₃N₅O₂

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