2-Methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

Base Information

Chemical Name:2-Methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine
CAS No.:717917-14-1
Molecular Formula:C₁₉H₁₉N₃O₂S
Molecular Weight:353.445
Hs Code.:
Mol file:717917-14-1.mol

Synonyms:2-methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine;

Suppliers and Price of 2-Methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 17 raw suppliers

Chemical Property of 2-Methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

Chemical Property:

Melting Point:111-112 °C
Boiling Point:639.471 °C at 760 mmHg
Flash Point:340.54 °C
PSA：74.44000
Density:1.328 g/cm³
LogP:4.59070

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

There total 7 articles about 2-Methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 29489-04-1
4-bromo-1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

: 124-42-5
acetamidine hydrochloride

: 2-methyl-6-[(4-methylphenyl)sulfonyl]-5,6-dihydro-4H[1,3]oxazolo[4,5-d][1]benzazepine

: 717917-14-1
2-methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

Guidance literature:: With potassium carbonate; In chloroform; for 96h; Heating;
DOI:10.3987/COM-04-10025

Reference yield:

: 24310-36-9
1-tosyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

: 717917-14-1
2-methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / pyridinium hydrobromide perbromide / CHCl₃ / 1 h / 15 - 30 °C

2: 28 percent / potassium carbonate / CHCl₃ / 96 h / Heating

With pyridinium hydrobromide perbromide; potassium carbonate; In chloroform;
DOI:10.3987/COM-04-10025

Reference yield:

: 50998-74-8
methyl N-tosylanthranilate

: 717917-14-1
2-methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / potassium carbonate; potassium iodide / butan-2-one / 12 h / Heating

2: 93 percent / potassium t-butoxide / dimethylformamide / 2 h / 0 - 5 °C

3: 97 percent / acetic acid; cc. HCl / 11 h / 80 °C

4: 89 percent / pyridinium hydrobromide perbromide / CHCl₃ / 1 h / 15 - 30 °C

5: 28 percent / potassium carbonate / CHCl₃ / 96 h / Heating

With hydrogenchloride; potassium tert-butylate; pyridinium hydrobromide perbromide; potassium carbonate; acetic acid; potassium iodide; In chloroform; N,N-dimethyl-formamide; butanone;
DOI:10.3987/COM-04-10025